{"author":[{"full_name":"Barton, Nicholas H","first_name":"Nicholas H","last_name":"Barton","orcid":"0000-0002-8548-5240","id":"4880FE40-F248-11E8-B48F-1D18A9856A87"}],"publication_status":"published","main_file_link":[{"url":"https://www.cambridge.org/core/journals/genetics-research/article/reduction-in-fixation-probability-caused-by-substitutions-at-linked-loci/458BBF3E7FE92E4EA6AFB2B000A98945"}],"_id":"3641","publist_id":"2742","date_created":"2018-12-11T12:04:23Z","extern":"1","issue":"3","language":[{"iso":"eng"}],"year":"1994","page":"199 - 208","title":"The reduction in fixation probability caused by substitutions at linked loci","type":"journal_article","citation":{"ieee":"N. H. Barton, “The reduction in fixation probability caused by substitutions at linked loci,” <i>Genetical Research</i>, vol. 64, no. 3. Cambridge University Press, pp. 199–208, 1994.","ista":"Barton NH. 1994. The reduction in fixation probability caused by substitutions at linked loci. Genetical Research. 64(3), 199–208.","mla":"Barton, Nicholas H. “The Reduction in Fixation Probability Caused by Substitutions at Linked Loci.” <i>Genetical Research</i>, vol. 64, no. 3, Cambridge University Press, 1994, pp. 199–208, doi:<a href=\"https://doi.org/10.1017/S0016672300032857 \">10.1017/S0016672300032857 </a>.","chicago":"Barton, Nicholas H. “The Reduction in Fixation Probability Caused by Substitutions at Linked Loci.” <i>Genetical Research</i>. Cambridge University Press, 1994. <a href=\"https://doi.org/10.1017/S0016672300032857 \">https://doi.org/10.1017/S0016672300032857 </a>.","ama":"Barton NH. The reduction in fixation probability caused by substitutions at linked loci. <i>Genetical Research</i>. 1994;64(3):199-208. doi:<a href=\"https://doi.org/10.1017/S0016672300032857 \">10.1017/S0016672300032857 </a>","apa":"Barton, N. H. (1994). The reduction in fixation probability caused by substitutions at linked loci. <i>Genetical Research</i>. Cambridge University Press. <a href=\"https://doi.org/10.1017/S0016672300032857 \">https://doi.org/10.1017/S0016672300032857 </a>","short":"N.H. Barton, Genetical Research 64 (1994) 199–208."},"status":"public","quality_controlled":"1","date_published":"1994-12-01T00:00:00Z","publication":"Genetical Research","month":"12","doi":"10.1017/S0016672300032857 ","publication_identifier":{"issn":["0016-6723"]},"date_updated":"2022-06-03T08:34:32Z","scopus_import":"1","article_processing_charge":"No","intvolume":"        64","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","article_type":"original","day":"01","volume":64,"oa_version":"None","publisher":"Cambridge University Press","abstract":[{"lang":"eng","text":"The probability of fixation of a mutation with selective advantage s will be reduced by substitutions at other loci. The effect of a single substitution, with selective advantage S0016672300032857inline1, can be approximated as a sudden reduction in the frequency of the favourable allele, by a fraction w = 1 −(s/S)r/s (where r is the recombination rate). An expression for the effect of a given sequence of such catastrophes is derived. This also applies to the ecological prxoblem of finding the probability that a small population will survive, despite occasional disasters. It is shown that if substitutions occur at a rate Δ, and are scattered randomly over a genetic map of length R, then an allele is unlikely to be fixed if its advantage is less than a critical value, Scrit = (π2/6)(2ΔS/(Rlog(S/s))). This threshold depends primarily on the variance in fitness per unit map length dueto substitutions, var(W)/R = 2ΔS/R. With no recombination, the fixation probability can be calculated for a finite population. If Δ &gt; s, it is of the same order as for a neutral allele ( ≈ Δ/(2N(Δ−s))), whilst if S0016672300032857inline2, fixation probability is much higher than for a neutral allele, but much lower than in the absence of hitch-hiking S0016672300032857inline3. These results suggest that hitch-hiking may substantially impede the accumulation of weakly favoured adaptations."}]}