---
res:
  bibo_abstract:
  - "The maintenance of polygenic variability by a balance between mutation and stabilizing
    selection has been analysed using two approximations: the ‘Gaussian’ and the ‘house
    of cards’. These lead to qualitatively different relationships between the equilibrium
    genetic variance and the parameters describing selection and mutation. Here we
    generalize these approximations to describe the dynamics of genetic means and
    variances under arbitrary patterns of selection and mutation. We incorporate genetic
    drift into the same mathematical framework.\r\nThe effects of frequency-independent
    selection and genetic drift can be determined from the gradient of log mean fitness
    and a covariance matrix that depends on genotype frequencies. These equations
    describe an ‘adaptive landscape’, with a natural metric of genetic distance set
    by the covariance matrix. From this representation we can change coordinates to
    derive equations describing the dynamics of an additive polygenic character in
    terms of the moments (means, variances, …) of allelic effects at individual loci.
    Only under certain simplifying conditions, such as those derived from the Gaussian
    and house-of-cards approximations, do these general recursions lead to tractable
    equations for the first few phenotypic moments. The alternative approximations
    differ in the constraints they impose on the distributions of allelic effects
    at individual loci. The Gaussian-based prediction that evolution of the phenotypic
    mean does not change the genetic variance is shown to be a consequence of the
    assumption that the allelic distributions are never skewed. We present both analytical
    and numerical results delimiting the parameter values consistent with our approximations.@eng"
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Nicholas H
      foaf_name: Barton, Nicholas H
      foaf_surname: Barton
      foaf_workInfoHomepage: http://www.librecat.org/personId=4880FE40-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-8548-5240
  - foaf_Person:
      foaf_givenName: Michael
      foaf_name: Turelli, Michael
      foaf_surname: Turelli
  bibo_doi: 10.1017/S0016672300026951
  bibo_issue: '2'
  bibo_volume: 49
  dct_date: 1987^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/0016-6723
  - http://id.crossref.org/issn/1469-5073
  dct_language: eng
  dct_publisher: Cambridge University Press@
  dct_title: Adaptive landscapes, genetic distance, and the evolution of quantitative
    characters@
...