article published yes Nicholas H Barton author 4880FE40-F248-11E8-B48F-1D18A9856A870000-0002-8548-5240 The rate of gene flow across a hybrid zone may be reduced by the presence of a physical barrier, by a reduction of population density caused by reduced fitness of hybrids (the “hybrid sink” effect), and by linkage. If the reduction in hybrid fitness is not extreme, the strength of the barrier to gene flow caused by these effects is. Here, w is the width of the cline; ρ* is the carrying capacity; W̄* is the mean fitness of the population, excluding effects of density; R is the strength of density-dependent regulation; and r̄ is the harmonic mean recombination rate between the locus whose flow is being calculated, and loci under selection. +, 0 denote populations outside the hybrid zone, and at its centre, respectively. This relation is illustrated using data from hybrid ones in Bombina and Podisma, and its implications for interpretation of data from nature are discussed. Nature Publishing Group1986 eng 0018-067X 1365-2540 57415 - 426 yes Barton, Nicholas H. “The Effects of Linkage and Density-Dependent Regulation on Gene Flow.” <i>Heredity</i>, vol. 57, Nature Publishing Group, 1986, pp. 415–26. Barton, Nicholas H. “The Effects of Linkage and Density-Dependent Regulation on Gene Flow.” <i>Heredity</i>. Nature Publishing Group, 1986. N. H. Barton, “The effects of linkage and density-dependent regulation on gene flow,” <i>Heredity</i>, vol. 57. Nature Publishing Group, pp. 415–426, 1986. Barton, N. H. (1986). The effects of linkage and density-dependent regulation on gene flow. <i>Heredity</i>. Nature Publishing Group. Barton NH. 1986. The effects of linkage and density-dependent regulation on gene flow. Heredity. 57, 415–426. N.H. Barton, Heredity 57 (1986) 415–426. Barton NH. The effects of linkage and density-dependent regulation on gene flow. <i>Heredity</i>. 1986;57:415-426. 36652018-12-11T12:04:30Z2022-02-01T14:31:29Z