---
res:
  bibo_abstract:
  - "Sex and recombination have long been seen as adaptations that facilitate natural
    selection by generating favorable variations. If recombination is to aid selection,
    there must be negative linkage disequilibria—favorable alleles must be found together
    less often than expected by chance. These negative linkage disequilibria can be
    generated directly by selection, but this must involve negative epistasis of just
    the right strength, which is not expected, from either experiment or theory. Random
    drift provides a more general source of negative associations: Favorable mutations
    almost always arise on different genomes, and negative associations tend to persist,
    precisely because they shield variation from selection.\r\n\r\nWe can understand
    how recombination aids adaptation by determining the maximum possible rate of
    adaptation. With unlinked loci, this rate increases only logarithmically with
    the influx of favorable mutations. With a linear genome, a scaling argument shows
    that in a large population, the rate of adaptive substitution depends only on
    the expected rate in the absence of interference, divided by the total rate of
    recombination. A two-locus approximation predicts an upper bound on the rate of
    substitution, proportional to recombination rate.\r\n\r\nIf associations between
    linked loci do impede adaptation, there can be substantial selection for modifiers
    that increase recombination. Whether this can account for the maintenance of high
    rates of sex and recombination depends on the extent of selection. It is clear
    that the rate of species-wide substitutions is typically far too low to generate
    appreciable selection for recombination. However, local sweeps within a subdivided
    population may be effective.@eng"
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Nicholas H
      foaf_name: Barton, Nicholas H
      foaf_surname: Barton
      foaf_workInfoHomepage: http://www.librecat.org/personId=4880FE40-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-8548-5240
  bibo_doi: 10.1101/sqb.2009.74.030
  bibo_volume: 74
  dct_date: 2009^xs_gYear
  dct_identifier:
  - UT:000578380600022
  dct_language: eng
  dct_publisher: Cold Spring Harbor Laboratory Press@
  dct_title: Why sex and recombination?@
...