---
_id: '3724'
abstract:
- lang: eng
text: 'Small photochromic molecules are widespread in nature and serve as switches
for a plethora of light-controlled processes. In a typical photoreceptor, the
different geometries and polarities of the photochrome isomers are tightly coupled
to functionally relevant conformational changes in the proteins. The past decade
has seen extensive efforts to mimic nature and create proteins controlled by synthetic
photochromes in the laboratory. Here, we discuss the role of molecular modeling
to gain a structural understanding of photochromes and to design light-controlled
peptides and proteins. We address several fundamental questions: What are the
molecular structures of photochromes, particularly for metastable isomers that
cannot be addressed experimentally? How are the structures of bistable photoisomers
coupled to the conformational states of peptides and proteins? Can we design light-controlled
proteins rapidly and reliably? After an introduction to the principles of molecular
modeling, we answer these questions by examining systems that range from the size
of isolated photochromes, to that of peptides and large cell surface receptors,
each from its unique computational perspective.'
author:
- first_name: Harald L
full_name: Harald Janovjak
id: 33BA6C30-F248-11E8-B48F-1D18A9856A87
last_name: Janovjak
orcid: 0000-0002-8023-9315
- first_name: Ehud
full_name: Isacoff, Ehud Y
last_name: Isacoff
citation:
ama: 'Janovjak HL, Isacoff E. Structure-based design of light-controlled proteins.
In: Photosensitive Molecules for the Control of Biological Function. Vol
55. Springer; 2011:233-266. doi:10.1007/978-1-61779-031-7_13'
apa: Janovjak, H. L., & Isacoff, E. (2011). Structure-based design of light-controlled
proteins. In Photosensitive Molecules for the Control of Biological Function
(Vol. 55, pp. 233–266). Springer. https://doi.org/10.1007/978-1-61779-031-7_13
chicago: Janovjak, Harald L, and Ehud Isacoff. “Structure-Based Design of Light-Controlled
Proteins.” In Photosensitive Molecules for the Control of Biological Function,
55:233–66. Springer, 2011. https://doi.org/10.1007/978-1-61779-031-7_13.
ieee: H. L. Janovjak and E. Isacoff, “Structure-based design of light-controlled
proteins,” in Photosensitive Molecules for the Control of Biological Function,
vol. 55, Springer, 2011, pp. 233–266.
ista: 'Janovjak HL, Isacoff E. 2011.Structure-based design of light-controlled proteins.
In: Photosensitive Molecules for the Control of Biological Function. vol. 55,
233–266.'
mla: Janovjak, Harald L., and Ehud Isacoff. “Structure-Based Design of Light-Controlled
Proteins.” Photosensitive Molecules for the Control of Biological Function,
vol. 55, Springer, 2011, pp. 233–66, doi:10.1007/978-1-61779-031-7_13.
short: H.L. Janovjak, E. Isacoff, in:, Photosensitive Molecules for the Control
of Biological Function, Springer, 2011, pp. 233–266.
date_created: 2018-12-11T12:04:49Z
date_published: 2011-03-16T00:00:00Z
date_updated: 2021-01-12T07:51:45Z
day: '16'
doi: 10.1007/978-1-61779-031-7_13
extern: 1
intvolume: ' 55'
month: '03'
page: 233 - 266
publication: Photosensitive Molecules for the Control of Biological Function
publication_status: published
publisher: Springer
publist_id: '2504'
quality_controlled: 0
status: public
title: Structure-based design of light-controlled proteins
type: book_chapter
volume: 55
year: '2011'
...