---
res:
  bibo_abstract:
  - Gene expression levels fluctuate even under constant external conditions. Much
    emphasis has usually been placed on the components of this noise that are due
    to randomness in transcription and translation. Here we focus on the role of noise
    associated with the inputs to transcriptional regulation; in particular, we analyze
    the effects of random arrival times and binding of transcription factors to their
    target sites along the genome. This contribution to the total noise sets a fundamental
    physical limit to the reliability of genetic control, and has clear signatures,
    but we show that these are easily obscured by experimental limitations and even
    by conventional methods for plotting the variance vs. mean expression level. We
    argue that simple, universal models of noise dominated by transcription and translation
    are inconsistent with the embedding of gene expression in a network of regulatory
    interactions. Analysis of recent experiments on transcriptional control in the
    early Drosophila embryo shows that these results are quantitatively consistent
    with the predicted signatures of input noise, and we discuss the experiments needed
    to test the importance of input noise more generally.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Gasper
      foaf_name: Tkacik, Gasper
      foaf_surname: Tkacik
      foaf_workInfoHomepage: http://www.librecat.org/personId=3D494DCA-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-6699-1455
  - foaf_Person:
      foaf_givenName: Thomas
      foaf_name: Gregor, Thomas
      foaf_surname: Gregor
  - foaf_Person:
      foaf_givenName: William
      foaf_name: Bialek, William
      foaf_surname: Bialek
  bibo_doi: 10.1371/journal.pone.0002774
  bibo_issue: '7'
  bibo_volume: 3
  dct_date: 2008^xs_gYear
  dct_language: eng
  dct_publisher: Public Library of Science@
  dct_title: The role of input noise in transcriptional regulation@
  fabio_hasPubmedId: '18648612'
...