---
res:
  bibo_abstract:
  - The chemotaxis signalling network in Escherichia coli that controls the locomotion
    of bacteria is a classic model system for signal transduction1, 2. This pathway
    modulates the behaviour of flagellar motors to propel bacteria towards sources
    of chemical attractants. Although this system relaxes to a steady state in response
    to environmental changes, the signalling events within the chemotaxis network
    are noisy and cause large temporal variations of the motor behaviour even in the
    absence of stimulus3. That the same signalling network governs both behavioural
    variability and cellular response raises the question of whether these two traits
    are independent. Here, we experimentally establish a fluctuation–response relationship
    in the chemotaxis system of living bacteria. Using this relationship, we demonstrate
    the possibility of inferring the cellular response from the behavioural variability
    measured before stimulus. In monitoring the pre- and post-stimulus switching behaviour
    of individual bacterial motors, we found that variability scales linearly with
    the response time for different functioning states of the cell. This study highlights
    that the fundamental relationship between fluctuation and response is not constrained
    to physical systems at thermodynamic equilibrium4 but is extensible to living
    cells5. Such a relationship not only implies that behavioural variability and
    cellular response can be coupled traits, but it also provides a general framework
    within which we can examine how the selection of a network design shapes this
    interdependence@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Heungwon
      foaf_name: Park, Heungwon
      foaf_surname: Park
  - foaf_Person:
      foaf_givenName: William
      foaf_name: Pontius, William
      foaf_surname: Pontius
  - foaf_Person:
      foaf_givenName: Calin C
      foaf_name: Calin Guet
      foaf_surname: Guet
      foaf_workInfoHomepage: http://www.librecat.org/personId=47F8433E-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-6220-2052
  - foaf_Person:
      foaf_givenName: John
      foaf_name: Marko, John F
      foaf_surname: Marko
  - foaf_Person:
      foaf_givenName: Thierry
      foaf_name: Emonet,Thierry
      foaf_surname: Emonet
  - foaf_Person:
      foaf_givenName: Philippe
      foaf_name: Cluzel,Philippe
      foaf_surname: Cluzel
  bibo_doi: 10.1038/nature09551
  bibo_volume: 468
  dct_date: 2010^xs_gYear
  dct_publisher: Nature Publishing Group@
  dct_title: Interdependence of behavioural variability and response to small stimuli
    in bacteria@
...