---
res:
  bibo_abstract:
  - A central problem in biology is determining how genes interact as parts of functional
    networks. Creation and analysis of synthetic networks, composed of well-characterized
    genetic elements, provide a framework for theoretical modeling. Here, with the
    use of a combinatorial method, a library of networks with varying connectivity
    was generated in Escherichia coli. These networks were composed of genes encoding
    the transcriptional regulators Lacl, TetR, and lambda Cl, as well as the corresponding
    promoters. They displayed phenotypic behaviors resembling binary logical circuits,
    with two chemical “inputs” and a fluorescent protein “output.” Within this simple
    system, diverse computational functions arose through changes in network connectivity.
    Combinatorial synthesis provides an alternative approach for studying biological
    networks, as well as an efficient method for producing diverse phenotypes in vivo.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Calin C
      foaf_name: Guet, Calin C
      foaf_surname: Guet
      foaf_workInfoHomepage: http://www.librecat.org/personId=47F8433E-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-6220-2052
  - foaf_Person:
      foaf_givenName: Michael
      foaf_name: Elowitz, Michael
      foaf_surname: Elowitz
  - foaf_Person:
      foaf_givenName: Weihong
      foaf_name: Hsing, Weihong
      foaf_surname: Hsing
  - foaf_Person:
      foaf_givenName: Stanislas
      foaf_name: Leibler, Stanislas
      foaf_surname: Leibler
  bibo_doi: 10.1126/science.1067407
  bibo_issue: '5572'
  bibo_volume: 296
  dct_date: 2002^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/0036-8075
  dct_language: eng
  dct_publisher: American Association for the Advancement of Science@
  dct_title: Combinatorial synthesis of genetic networks@
  fabio_hasPubmedId: '12029133'
...