---
res:
  bibo_abstract:
  - 'GABAergic interneurones are diverse in their morphological and functional properties.
    Perisomatic inhibitory cells show fast spiking during sustained current injection,
    whereas dendritic inhibitory cells fire action potentials with lower frequency.
    We examined functional and molecular properties of K(+) channels in interneurones
    with horizontal dendrites in stratum oriens-alveus (OA) of the hippocampal CA1
    region, which mainly comprise somatostatin-positive dendritic inhibitory cells.
    Voltage-gated K(+) currents in nucleated patches isolated from OA interneurones
    consisted of three major components: a fast delayed rectifier K(+) current component
    that was highly sensitive to external 4-aminopyridine (4-AP) and tetraethylammonium
    (TEA) (half-maximal inhibitory concentrations < 0.1 mM for both blockers),
    a slow delayed rectifier K(+) current component that was sensitive to high concentrations
    of TEA, but insensitive to 4-AP, and a rapidly inactivating A-type K(+) current
    component that was blocked by high concentrations of 4-AP, but resistant to TEA.
    The relative contributions of these components to the macroscopic K(+) current
    were estimated as 57 +/- 5, 25 +/- 6, and 19 +/- 2 %, respectively. Dendrotoxin,
    a selective blocker of Kv1 channels had only minimal effects on K(+) currents
    in nucleated patches. Coapplication of the membrane-permeant cAMP analogue 8-(4-chlorophenylthio)-adenosine
    3'':5''-cyclic monophosphate (cpt-cAMP) and the phosphodiesterase blocker isobutyl-methylxanthine
    (IBMX) resulted in a selective inhibition of the fast delayed rectifier K(+) current
    component. This inhibition was absent in the presence of the protein kinase A
    (PKA) inhibitor H-89, implying the involvement of PKA-mediated phosphorylation.
    Single-cell reverse transcription-polymerase chain reaction (RT-PCR) analysis
    revealed a high abundance of Kv3.2 mRNA in OA interneurones, whereas the expression
    level of Kv3.1 mRNA was markedly lower. Similarly, RT-PCR analysis showed a high
    abundance of Kv4.3 mRNA, whereas Kv4.2 mRNA was undetectable. This suggests that
    the fast delayed rectifier K(+) current and the A-type K(+) current component
    are mediated predominantly by homomeric Kv3.2 and Kv4.3 channels. Selective modulation
    of Kv3.2 channels in OA interneurones by cAMP is likely to be an important factor
    regulating the activity of dendritic inhibitory cells in principal neurone-interneurone
    microcircuits.@eng'
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Cheng
      foaf_name: Lien, Cheng
      foaf_surname: Lien
  - foaf_Person:
      foaf_givenName: Marco
      foaf_name: Martina, Marco
      foaf_surname: Martina
  - foaf_Person:
      foaf_givenName: Jobst
      foaf_name: Schultz, Jobst
      foaf_surname: Schultz
  - foaf_Person:
      foaf_givenName: Heimo
      foaf_name: Ehmke, Heimo
      foaf_surname: Ehmke
  - foaf_Person:
      foaf_givenName: Peter M
      foaf_name: Jonas, Peter M
      foaf_surname: Jonas
      foaf_workInfoHomepage: http://www.librecat.org/personId=353C1B58-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-5001-4804
  bibo_doi: 10.1113/jphysiol.2001.013066
  bibo_issue: Pt 2
  bibo_volume: 538
  dct_date: 2002^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/0022-3751
  dct_language: eng
  dct_publisher: Wiley-Blackwell@
  dct_title: Gating, modulation and subunit composition of voltage-gated K(+) channels
    in dendritic inhibitory interneurones of rat hippocampus@
  fabio_hasPubmedId: '11790809'
...