A large pool of releasable vesicles in a cortical glutamatergic synapse Hallermann, Stefan Pawlu, Christian Jonas, Peter M ; https://orcid.org/0000-0001-5001-4804 Heckmann, Manfred To probe exocytosis at a cortical glutamatergic synapse, we made capacitance measurements in whole-cell recorded hippocampal mossy fiber terminals. Evaluation of different methods by using a morphology-based equivalent electrical model revealed that quantitative capacitance measurements are possible in this presynaptic structure. Voltage pulses leading to presynaptic Ca2+ inflow evoked large capacitance signals that showed saturation with increasing pulse duration. The mean peak capacitance increase was 100 fF, corresponding to a pool of approximately 1,400 releasable vesicles. Thus hippocampal mossy fiber synapses have a vesicular &quot;maxipool.&quot; Large pool size and rapid vesicle recycling may underlie the uniquely large extent of activity-dependent plasticity in this synapse. National Academy of Sciences 2003 info:eu-repo/semantics/article doc-type:article text http://purl.org/coar/resource_type/c_2df8fbb1 https://research-explorer.ista.ac.at/record/3806 Hallermann S, Pawlu C, Jonas PM, Heckmann M. A large pool of releasable vesicles in a cortical glutamatergic synapse. <i>Proceedings of the National Acadamy of Science</i>. 2003;100(15):8975-8980. doi:<a href="https://doi.org/10.1073/pnas.1432836100">10.1073/pnas.1432836100</a> eng info:eu-repo/semantics/altIdentifier/doi/10.1073/pnas.1432836100 info:eu-repo/semantics/altIdentifier/e-issn/1091-6490 info:eu-repo/semantics/altIdentifier/issn-l/0027-8424 info:eu-repo/semantics/altIdentifier/pmid/12815098 info:eu-repo/semantics/closedAccess