{"article_processing_charge":"No","day":"18","year":"2003","abstract":[{"lang":"eng","text":"To probe exocytosis at a cortical glutamatergic synapse, we made capacitance measurements in whole-cell recorded hippocampal mossy fiber terminals. Evaluation of different methods by using a morphology-based equivalent electrical model revealed that quantitative capacitance measurements are possible in this presynaptic structure. Voltage pulses leading to presynaptic Ca2+ inflow evoked large capacitance signals that showed saturation with increasing pulse duration. The mean peak capacitance increase was 100 fF, corresponding to a pool of approximately 1,400 releasable vesicles. Thus hippocampal mossy fiber synapses have a vesicular &quot;maxipool.&quot; Large pool size and rapid vesicle recycling may underlie the uniquely large extent of activity-dependent plasticity in this synapse."}],"extern":"1","page":"8975 - 8980","_id":"3806","OA_type":"closed access","scopus_import":"1","author":[{"last_name":"Hallermann","full_name":"Hallermann, Stefan","first_name":"Stefan"},{"first_name":"Christian","full_name":"Pawlu, Christian","last_name":"Pawlu"},{"last_name":"Jonas","orcid":"0000-0001-5001-4804","full_name":"Jonas, Peter M","first_name":"Peter M","id":"353C1B58-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Heckmann, Manfred","last_name":"Heckmann","first_name":"Manfred"}],"intvolume":"       100","doi":"10.1073/pnas.1432836100","pmid":1,"date_created":"2018-12-11T12:05:16Z","publisher":"National Academy of Sciences","publist_id":"2405","date_published":"2003-06-18T00:00:00Z","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","status":"public","publication_status":"published","citation":{"apa":"Hallermann, S., Pawlu, C., Jonas, P. M., &#38; Heckmann, M. (2003). A large pool of releasable vesicles in a cortical glutamatergic synapse. <i>Proceedings of the National Acadamy of Science</i>. National Academy of Sciences. <a href=\"https://doi.org/10.1073/pnas.1432836100\">https://doi.org/10.1073/pnas.1432836100</a>","short":"S. Hallermann, C. Pawlu, P.M. Jonas, M. Heckmann, Proceedings of the National Acadamy of Science 100 (2003) 8975–8980.","ama":"Hallermann S, Pawlu C, Jonas PM, Heckmann M. A large pool of releasable vesicles in a cortical glutamatergic synapse. <i>Proceedings of the National Acadamy of Science</i>. 2003;100(15):8975-8980. doi:<a href=\"https://doi.org/10.1073/pnas.1432836100\">10.1073/pnas.1432836100</a>","mla":"Hallermann, Stefan, et al. “A Large Pool of Releasable Vesicles in a Cortical Glutamatergic Synapse.” <i>Proceedings of the National Acadamy of Science</i>, vol. 100, no. 15, National Academy of Sciences, 2003, pp. 8975–80, doi:<a href=\"https://doi.org/10.1073/pnas.1432836100\">10.1073/pnas.1432836100</a>.","ista":"Hallermann S, Pawlu C, Jonas PM, Heckmann M. 2003. A large pool of releasable vesicles in a cortical glutamatergic synapse. Proceedings of the National Acadamy of Science. 100(15), 8975–8980.","ieee":"S. Hallermann, C. Pawlu, P. M. Jonas, and M. Heckmann, “A large pool of releasable vesicles in a cortical glutamatergic synapse,” <i>Proceedings of the National Acadamy of Science</i>, vol. 100, no. 15. National Academy of Sciences, pp. 8975–8980, 2003.","chicago":"Hallermann, Stefan, Christian Pawlu, Peter M Jonas, and Manfred Heckmann. “A Large Pool of Releasable Vesicles in a Cortical Glutamatergic Synapse.” <i>Proceedings of the National Acadamy of Science</i>. National Academy of Sciences, 2003. <a href=\"https://doi.org/10.1073/pnas.1432836100\">https://doi.org/10.1073/pnas.1432836100</a>."},"type":"journal_article","issue":"15","title":"A large pool of releasable vesicles in a cortical glutamatergic synapse","external_id":{"pmid":["12815098"]},"article_type":"original","date_updated":"2026-05-08T09:40:06Z","quality_controlled":"1","oa_version":"None","publication_identifier":{"eissn":["1091-6490"],"issnl":["0027-8424"]},"language":[{"iso":"eng"}],"volume":100,"publication":"Proceedings of the National Acadamy of Science","month":"06"}