---
OA_type: closed access
_id: '3806'
abstract:
- lang: eng
  text: To probe exocytosis at a cortical glutamatergic synapse, we made capacitance
    measurements in whole-cell recorded hippocampal mossy fiber terminals. Evaluation
    of different methods by using a morphology-based equivalent electrical model revealed
    that quantitative capacitance measurements are possible in this presynaptic structure.
    Voltage pulses leading to presynaptic Ca2+ inflow evoked large capacitance signals
    that showed saturation with increasing pulse duration. The mean peak capacitance
    increase was 100 fF, corresponding to a pool of approximately 1,400 releasable
    vesicles. Thus hippocampal mossy fiber synapses have a vesicular "maxipool."
    Large pool size and rapid vesicle recycling may underlie the uniquely large extent
    of activity-dependent plasticity in this synapse.
article_processing_charge: No
article_type: original
author:
- first_name: Stefan
  full_name: Hallermann, Stefan
  last_name: Hallermann
- first_name: Christian
  full_name: Pawlu, Christian
  last_name: Pawlu
- first_name: Peter M
  full_name: Jonas, Peter M
  id: 353C1B58-F248-11E8-B48F-1D18A9856A87
  last_name: Jonas
  orcid: 0000-0001-5001-4804
- first_name: Manfred
  full_name: Heckmann, Manfred
  last_name: Heckmann
citation:
  ama: Hallermann S, Pawlu C, Jonas PM, Heckmann M. A large pool of releasable vesicles
    in a cortical glutamatergic synapse. <i>Proceedings of the National Acadamy of
    Science</i>. 2003;100(15):8975-8980. doi:<a href="https://doi.org/10.1073/pnas.1432836100">10.1073/pnas.1432836100</a>
  apa: Hallermann, S., Pawlu, C., Jonas, P. M., &#38; Heckmann, M. (2003). A large
    pool of releasable vesicles in a cortical glutamatergic synapse. <i>Proceedings
    of the National Acadamy of Science</i>. National Academy of Sciences. <a href="https://doi.org/10.1073/pnas.1432836100">https://doi.org/10.1073/pnas.1432836100</a>
  chicago: Hallermann, Stefan, Christian Pawlu, Peter M Jonas, and Manfred Heckmann.
    “A Large Pool of Releasable Vesicles in a Cortical Glutamatergic Synapse.” <i>Proceedings
    of the National Acadamy of Science</i>. National Academy of Sciences, 2003. <a
    href="https://doi.org/10.1073/pnas.1432836100">https://doi.org/10.1073/pnas.1432836100</a>.
  ieee: S. Hallermann, C. Pawlu, P. M. Jonas, and M. Heckmann, “A large pool of releasable
    vesicles in a cortical glutamatergic synapse,” <i>Proceedings of the National
    Acadamy of Science</i>, vol. 100, no. 15. National Academy of Sciences, pp. 8975–8980,
    2003.
  ista: Hallermann S, Pawlu C, Jonas PM, Heckmann M. 2003. A large pool of releasable
    vesicles in a cortical glutamatergic synapse. Proceedings of the National Acadamy
    of Science. 100(15), 8975–8980.
  mla: Hallermann, Stefan, et al. “A Large Pool of Releasable Vesicles in a Cortical
    Glutamatergic Synapse.” <i>Proceedings of the National Acadamy of Science</i>,
    vol. 100, no. 15, National Academy of Sciences, 2003, pp. 8975–80, doi:<a href="https://doi.org/10.1073/pnas.1432836100">10.1073/pnas.1432836100</a>.
  short: S. Hallermann, C. Pawlu, P.M. Jonas, M. Heckmann, Proceedings of the National
    Acadamy of Science 100 (2003) 8975–8980.
date_created: 2018-12-11T12:05:16Z
date_published: 2003-06-18T00:00:00Z
date_updated: 2026-05-08T09:40:06Z
day: '18'
doi: 10.1073/pnas.1432836100
extern: '1'
external_id:
  pmid:
  - '12815098'
intvolume: '       100'
issue: '15'
language:
- iso: eng
month: '06'
oa_version: None
page: 8975 - 8980
pmid: 1
publication: Proceedings of the National Acadamy of Science
publication_identifier:
  eissn:
  - 1091-6490
  issnl:
  - 0027-8424
publication_status: published
publisher: National Academy of Sciences
publist_id: '2405'
quality_controlled: '1'
scopus_import: '1'
status: public
title: A large pool of releasable vesicles in a cortical glutamatergic synapse
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 100
year: '2003'
...