{"_id":"3808","publication":"Neuron","status":"public","year":"2005","extern":1,"volume":45,"day":"01","citation":{"apa":"Engel, D., &#38; Jonas, P. M. (2005). Presynaptic action potential amplification by voltage-gated Na+ channels in hippocampal mossy fiber boutons. <i>Neuron</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.neuron.2004.12.048 \">https://doi.org/10.1016/j.neuron.2004.12.048 </a>","ista":"Engel D, Jonas PM. 2005. Presynaptic action potential amplification by voltage-gated Na+ channels in hippocampal mossy fiber boutons. Neuron. 45(3), 405–17.","chicago":"Engel, Dominique, and Peter M Jonas. “Presynaptic Action Potential Amplification by Voltage-Gated Na+ Channels in Hippocampal Mossy Fiber Boutons.” <i>Neuron</i>. Elsevier, 2005. <a href=\"https://doi.org/10.1016/j.neuron.2004.12.048 \">https://doi.org/10.1016/j.neuron.2004.12.048 </a>.","ieee":"D. Engel and P. M. Jonas, “Presynaptic action potential amplification by voltage-gated Na+ channels in hippocampal mossy fiber boutons,” <i>Neuron</i>, vol. 45, no. 3. Elsevier, pp. 405–17, 2005.","mla":"Engel, Dominique, and Peter M. Jonas. “Presynaptic Action Potential Amplification by Voltage-Gated Na+ Channels in Hippocampal Mossy Fiber Boutons.” <i>Neuron</i>, vol. 45, no. 3, Elsevier, 2005, pp. 405–17, doi:<a href=\"https://doi.org/10.1016/j.neuron.2004.12.048 \">10.1016/j.neuron.2004.12.048 </a>.","short":"D. Engel, P.M. Jonas, Neuron 45 (2005) 405–17.","ama":"Engel D, Jonas PM. Presynaptic action potential amplification by voltage-gated Na+ channels in hippocampal mossy fiber boutons. <i>Neuron</i>. 2005;45(3):405-417. doi:<a href=\"https://doi.org/10.1016/j.neuron.2004.12.048 \">10.1016/j.neuron.2004.12.048 </a>"},"type":"journal_article","issue":"3","publisher":"Elsevier","publist_id":"2400","publication_status":"published","author":[{"full_name":"Engel, Dominique","first_name":"Dominique","last_name":"Engel"},{"last_name":"Jonas","first_name":"Peter M","full_name":"Peter Jonas","orcid":"0000-0001-5001-4804","id":"353C1B58-F248-11E8-B48F-1D18A9856A87"}],"month":"01","intvolume":"        45","quality_controlled":0,"title":"Presynaptic action potential amplification by voltage-gated Na+ channels in hippocampal mossy fiber boutons","doi":"10.1016/j.neuron.2004.12.048 ","date_updated":"2021-01-12T07:52:21Z","date_created":"2018-12-11T12:05:17Z","page":"405 - 17","date_published":"2005-01-01T00:00:00Z","abstract":[{"lang":"eng","text":"Action potentials in central neurons are initiated near the axon initial segment, propagate into the axon, and finally invade the presynaptic terminals, where they trigger transmitter release. Voltage-gated Na(+) channels are key determinants of excitability, but Na(+) channel density and properties in axons and presynaptic terminals of cortical neurons have not been examined yet. In hippocampal mossy fiber boutons, which emerge from parent axons en passant, Na(+) channels are very abundant, with an estimated number of approximately 2000 channels per bouton. Presynaptic Na(+) channels show faster inactivation kinetics than somatic channels, suggesting differences between subcellular compartments of the same cell. Computational analysis of action potential propagation in axon-multibouton structures reveals that Na(+) channels in boutons preferentially amplify the presynaptic action potential and enhance Ca(2+) inflow, whereas Na(+) channels in axons control the reliability and speed of propagation. Thus, presynaptic and axonal Na(+) channels contribute differentially to mossy fiber synaptic transmission."}]}