{"extern":1,"publication":"Neuron","publication_status":"published","publist_id":"2400","month":"01","day":"01","type":"journal_article","issue":"3","_id":"3808","date_updated":"2021-01-12T07:52:21Z","citation":{"ista":"Engel D, Jonas PM. 2005. Presynaptic action potential amplification by voltage-gated Na+ channels in hippocampal mossy fiber boutons. Neuron. 45(3), 405–17.","chicago":"Engel, Dominique, and Peter M Jonas. “Presynaptic Action Potential Amplification by Voltage-Gated Na+ Channels in Hippocampal Mossy Fiber Boutons.” Neuron. Elsevier, 2005. https://doi.org/10.1016/j.neuron.2004.12.048 .","short":"D. Engel, P.M. Jonas, Neuron 45 (2005) 405–17.","apa":"Engel, D., & Jonas, P. M. (2005). Presynaptic action potential amplification by voltage-gated Na+ channels in hippocampal mossy fiber boutons. Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2004.12.048 ","ieee":"D. Engel and P. M. Jonas, “Presynaptic action potential amplification by voltage-gated Na+ channels in hippocampal mossy fiber boutons,” Neuron, vol. 45, no. 3. Elsevier, pp. 405–17, 2005.","ama":"Engel D, Jonas PM. Presynaptic action potential amplification by voltage-gated Na+ channels in hippocampal mossy fiber boutons. Neuron. 2005;45(3):405-417. doi:10.1016/j.neuron.2004.12.048 ","mla":"Engel, Dominique, and Peter M. Jonas. “Presynaptic Action Potential Amplification by Voltage-Gated Na+ Channels in Hippocampal Mossy Fiber Boutons.” Neuron, vol. 45, no. 3, Elsevier, 2005, pp. 405–17, doi:10.1016/j.neuron.2004.12.048 ."},"publisher":"Elsevier","doi":"10.1016/j.neuron.2004.12.048 ","date_published":"2005-01-01T00:00:00Z","quality_controlled":0,"intvolume":" 45","title":"Presynaptic action potential amplification by voltage-gated Na+ channels in hippocampal mossy fiber boutons","volume":45,"page":"405 - 17","status":"public","author":[{"last_name":"Engel","first_name":"Dominique","full_name":"Engel, Dominique"},{"last_name":"Jonas","orcid":"0000-0001-5001-4804","full_name":"Peter Jonas","id":"353C1B58-F248-11E8-B48F-1D18A9856A87","first_name":"Peter M"}],"date_created":"2018-12-11T12:05:17Z","year":"2005","abstract":[{"lang":"eng","text":"Action potentials in central neurons are initiated near the axon initial segment, propagate into the axon, and finally invade the presynaptic terminals, where they trigger transmitter release. Voltage-gated Na(+) channels are key determinants of excitability, but Na(+) channel density and properties in axons and presynaptic terminals of cortical neurons have not been examined yet. In hippocampal mossy fiber boutons, which emerge from parent axons en passant, Na(+) channels are very abundant, with an estimated number of approximately 2000 channels per bouton. Presynaptic Na(+) channels show faster inactivation kinetics than somatic channels, suggesting differences between subcellular compartments of the same cell. Computational analysis of action potential propagation in axon-multibouton structures reveals that Na(+) channels in boutons preferentially amplify the presynaptic action potential and enhance Ca(2+) inflow, whereas Na(+) channels in axons control the reliability and speed of propagation. Thus, presynaptic and axonal Na(+) channels contribute differentially to mossy fiber synaptic transmission."}]}