---
_id: '3811'
abstract:
- lang: eng
text: Networks of GABAergic neurons are key elements in the generation of gamma
oscillations in the brain. Computational studies suggested that the emergence
of coherent oscillations requires hyperpolarizing inhibition. Here, we show that
GABA(A) receptor-mediated inhibition in mature interneurons of the hippocampal
dentate gyrus is shunting rather than hyperpolarizing. Unexpectedly, when shunting
inhibition is incorporated into a structured interneuron network model with fast
and strong synapses, coherent oscillations emerge. In comparison to hyperpolarizing
inhibition, networks with shunting inhibition show several advantages. First,
oscillations are generated with smaller tonic excitatory drive. Second, network
frequencies are tuned to the gamma band. Finally, robustness against heterogeneity
in the excitatory drive is markedly improved. In single interneurons, shunting
inhibition shortens the interspike interval for low levels of drive but prolongs
it for high levels, leading to homogenization of neuronal firing rates. Thus,
shunting inhibition may confer increased robustness to gamma oscillations in the
brain.
author:
- first_name: Imre
full_name: Vida, Imre
last_name: Vida
- first_name: Marlene
full_name: Bartos, Marlene
last_name: Bartos
- first_name: Peter M
full_name: Peter Jonas
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: Vida I, Bartos M, Jonas PM. Shunting inhibition improves robustness of gamma
oscillations in hippocampal interneuron networks by homogenizing firing rates.
Neuron. 2006;49(1):107-117. doi:10.1016/j.neuron.2005.11.036
apa: Vida, I., Bartos, M., & Jonas, P. M. (2006). Shunting inhibition improves
robustness of gamma oscillations in hippocampal interneuron networks by homogenizing
firing rates. Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2005.11.036
chicago: Vida, Imre, Marlene Bartos, and Peter M Jonas. “Shunting Inhibition Improves
Robustness of Gamma Oscillations in Hippocampal Interneuron Networks by Homogenizing
Firing Rates.” Neuron. Elsevier, 2006. https://doi.org/10.1016/j.neuron.2005.11.036.
ieee: I. Vida, M. Bartos, and P. M. Jonas, “Shunting inhibition improves robustness
of gamma oscillations in hippocampal interneuron networks by homogenizing firing
rates,” Neuron, vol. 49, no. 1. Elsevier, pp. 107–17, 2006.
ista: Vida I, Bartos M, Jonas PM. 2006. Shunting inhibition improves robustness
of gamma oscillations in hippocampal interneuron networks by homogenizing firing
rates. Neuron. 49(1), 107–17.
mla: Vida, Imre, et al. “Shunting Inhibition Improves Robustness of Gamma Oscillations
in Hippocampal Interneuron Networks by Homogenizing Firing Rates.” Neuron,
vol. 49, no. 1, Elsevier, 2006, pp. 107–17, doi:10.1016/j.neuron.2005.11.036.
short: I. Vida, M. Bartos, P.M. Jonas, Neuron 49 (2006) 107–17.
date_created: 2018-12-11T12:05:18Z
date_published: 2006-01-01T00:00:00Z
date_updated: 2021-01-12T07:52:22Z
day: '01'
doi: 10.1016/j.neuron.2005.11.036
extern: 1
intvolume: ' 49'
issue: '1'
month: '01'
page: 107 - 17
publication: Neuron
publication_status: published
publisher: Elsevier
publist_id: '2398'
quality_controlled: 0
status: public
title: Shunting inhibition improves robustness of gamma oscillations in hippocampal
interneuron networks by homogenizing firing rates
type: journal_article
volume: 49
year: '2006'
...