{"doi":"10.1038/nn1542","author":[{"last_name":"Hefft","first_name":"Stefan","full_name":"Hefft, Stefan"},{"first_name":"Peter M","last_name":"Jonas","full_name":"Peter Jonas","orcid":"0000-0001-5001-4804","id":"353C1B58-F248-11E8-B48F-1D18A9856A87"}],"month":"01","citation":{"chicago":"Hefft, Stefan, and Peter M Jonas. “Asynchronous GABA Release Generates Long-Lasting Inhibition at a Hippocampal Interneuron-Principal Neuron Synapse (Review).” <i>Nature Neuroscience</i>. Nature Publishing Group, 2005. <a href=\"https://doi.org/10.1038/nn1542\">https://doi.org/10.1038/nn1542</a>.","ista":"Hefft S, Jonas PM. 2005. Asynchronous GABA release generates long-lasting inhibition at a hippocampal interneuron-principal neuron synapse (Review). Nature Neuroscience. 8(10), 1319–28.","ama":"Hefft S, Jonas PM. Asynchronous GABA release generates long-lasting inhibition at a hippocampal interneuron-principal neuron synapse (Review). <i>Nature Neuroscience</i>. 2005;8(10):1319-1328. doi:<a href=\"https://doi.org/10.1038/nn1542\">10.1038/nn1542</a>","ieee":"S. Hefft and P. M. Jonas, “Asynchronous GABA release generates long-lasting inhibition at a hippocampal interneuron-principal neuron synapse (Review),” <i>Nature Neuroscience</i>, vol. 8, no. 10. Nature Publishing Group, pp. 1319–28, 2005.","mla":"Hefft, Stefan, and Peter M. Jonas. “Asynchronous GABA Release Generates Long-Lasting Inhibition at a Hippocampal Interneuron-Principal Neuron Synapse (Review).” <i>Nature Neuroscience</i>, vol. 8, no. 10, Nature Publishing Group, 2005, pp. 1319–28, doi:<a href=\"https://doi.org/10.1038/nn1542\">10.1038/nn1542</a>.","apa":"Hefft, S., &#38; Jonas, P. M. (2005). Asynchronous GABA release generates long-lasting inhibition at a hippocampal interneuron-principal neuron synapse (Review). <i>Nature Neuroscience</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/nn1542\">https://doi.org/10.1038/nn1542</a>","short":"S. Hefft, P.M. Jonas, Nature Neuroscience 8 (2005) 1319–28."},"abstract":[{"text":"Hippocampal GABAergic interneurons show diverse molecular and morphological properties. The functional significance of this diversity for information processing is poorly understood. Here we show that cholecystokinin (CCK)-expressing interneurons in rat dentate gyrus release GABA in a highly asynchronous manner, in contrast to parvalbumin (PV) interneurons. With a gamma-frequency burst of ten action potentials, the ratio of asynchronous to synchronous release is 3:1 in CCK interneurons but is 1:5 in parvalbumin interneurons. N-type channels trigger synchronous and asynchronous release in CCK interneuron synapses, whereas P/Q-type Ca(2+) channels mediate release at PV interneuron synapses. Effects of Ca(2+) chelators suggest that both a long-lasting presynaptic Ca(2+) transient and a large distance between Ca(2+) source and sensor of exocytosis contribute to the higher ratio of asynchronous to synchronous release in CCK interneuron synapses. Asynchronous release occurs at physiological temperature and with behaviorally relevant stimulation patterns, thus generating long-lasting inhibition in the brain.","lang":"eng"}],"day":"01","publication_status":"published","publist_id":"2399","date_updated":"2019-04-26T07:22:35Z","publication":"Nature Neuroscience","status":"public","_id":"3812","date_published":"2005-01-01T00:00:00Z","page":"1319 - 28","volume":8,"issue":"10","extern":1,"intvolume":"         8","quality_controlled":0,"title":"Asynchronous GABA release generates long-lasting inhibition at a hippocampal interneuron-principal neuron synapse (Review)","type":"review","year":"2005","date_created":"2018-12-11T12:05:18Z","publisher":"Nature Publishing Group"}