---
_id: '3822'
abstract:
- lang: eng
text: Dentate gyrus granule cells transmit action potentials (APs) along their unmyelinated
mossy fibre axons to the CA3 region. Although the initiation and propagation of
APs are fundamental steps during neural computation, little is known about the
site of AP initiation and the speed of propagation in mossy fibre axons. To address
these questions, we performed simultaneous somatic and axonal whole-cell recordings
from granule cells in acute hippocampal slices of adult mice at approximately
23 degrees C. Injection of short current pulses or synaptic stimulation evoked
axonal and somatic APs with similar amplitudes. By contrast, the time course was
significantly different, as axonal APs had a higher maximal rate of rise (464
+/- 30 V s(-1) in the axon versus 297 +/- 12 V s(-1) in the soma, mean +/- s.e.m.).
Furthermore, analysis of latencies between the axonal and somatic signals showed
that APs were initiated in the proximal axon at approximately 20-30 mum distance
from the soma, and propagated orthodromically with a velocity of 0.24 m s(-1).
Qualitatively similar results were obtained at a recording temperature of approximately
34 degrees C. Modelling of AP propagation in detailed cable models of granule
cells suggested that a approximately 4 times higher Na(+) channel density ( approximately
1000 pS mum(-2)) in the axon might account for both the higher rate of rise of
axonal APs and the robust AP initiation in the proximal mossy fibre axon. This
may be of critical importance to separate dendritic integration of thousands of
synaptic inputs from the generation and transmission of a common AP output.
author:
- first_name: Christoph
full_name: Schmidt-Hieber, Christoph
last_name: Schmidt Hieber
- first_name: Peter M
full_name: Peter Jonas
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
- first_name: Josef
full_name: Bischofberger, Josef
last_name: Bischofberger
citation:
ama: Schmidt Hieber C, Jonas PM, Bischofberger J. Action potential initiation and
propagation in hippocampal mossy fibre axons. Journal of Physiology. 2008;586(7):1849-1857.
doi:10.1113/jphysiol.2007.150151
apa: Schmidt Hieber, C., Jonas, P. M., & Bischofberger, J. (2008). Action potential
initiation and propagation in hippocampal mossy fibre axons. Journal of Physiology.
Wiley-Blackwell. https://doi.org/10.1113/jphysiol.2007.150151
chicago: Schmidt Hieber, Christoph, Peter M Jonas, and Josef Bischofberger. “Action
Potential Initiation and Propagation in Hippocampal Mossy Fibre Axons.” Journal
of Physiology. Wiley-Blackwell, 2008. https://doi.org/10.1113/jphysiol.2007.150151 .
ieee: C. Schmidt Hieber, P. M. Jonas, and J. Bischofberger, “Action potential initiation
and propagation in hippocampal mossy fibre axons,” Journal of Physiology,
vol. 586, no. 7. Wiley-Blackwell, pp. 1849–57, 2008.
ista: Schmidt Hieber C, Jonas PM, Bischofberger J. 2008. Action potential initiation
and propagation in hippocampal mossy fibre axons. Journal of Physiology. 586(7),
1849–57.
mla: Schmidt Hieber, Christoph, et al. “Action Potential Initiation and Propagation
in Hippocampal Mossy Fibre Axons.” Journal of Physiology, vol. 586, no.
7, Wiley-Blackwell, 2008, pp. 1849–57, doi:10.1113/jphysiol.2007.150151 .
short: C. Schmidt Hieber, P.M. Jonas, J. Bischofberger, Journal of Physiology 586
(2008) 1849–57.
date_created: 2018-12-11T12:05:21Z
date_published: 2008-01-01T00:00:00Z
date_updated: 2021-01-12T07:52:27Z
day: '01'
doi: '10.1113/jphysiol.2007.150151 '
extern: 1
intvolume: ' 586'
issue: '7'
main_file_link:
- open_access: '1'
url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375716/
month: '01'
oa: 1
page: 1849 - 57
publication: Journal of Physiology
publication_status: published
publisher: Wiley-Blackwell
publist_id: '2387'
quality_controlled: 0
status: public
title: Action potential initiation and propagation in hippocampal mossy fibre axons
type: journal_article
volume: 586
year: '2008'
...