--- res: bibo_abstract: - Fast-spiking, parvalbumin-expressing basket cells (BCs) play a key role in feedforward and feedback inhibition in the hippocampus. However, the dendritic mechanisms underlying rapid interneuron recruitment have remained unclear. To quantitatively address this question, we developed detailed passive cable models of BCs in the dentate gyrus based on dual somatic or somatodendritic recordings and complete morphologic reconstructions. Both specific membrane capacitance and axial resistivity were comparable to those of pyramidal neurons, but the average somatodendritic specific membrane resistance (R(m)) was substantially lower in BCs. Furthermore, R(m) was markedly nonuniform, being lowest in soma and proximal dendrites, intermediate in distal dendrites, and highest in the axon. Thus, the somatodendritic gradient of R(m) was the reverse of that in pyramidal neurons. Further computational analysis revealed that these unique cable properties accelerate the time course of synaptic potentials at the soma in response to fast inputs, while boosting the efficacy of slow distal inputs. These properties will facilitate both rapid phasic and efficient tonic activation of BCs in hippocampal microcircuits.@eng bibo_authorlist: - foaf_Person: foaf_givenName: Anja foaf_name: Norenberg, Anja foaf_surname: Norenberg - foaf_Person: foaf_givenName: Hua foaf_name: Hua Hu foaf_surname: Hu foaf_workInfoHomepage: http://www.librecat.org/personId=4AC0145C-F248-11E8-B48F-1D18A9856A87 - foaf_Person: foaf_givenName: Imre foaf_name: Vida, Imre foaf_surname: Vida - foaf_Person: foaf_givenName: Marlene foaf_name: Bartos, Marlene foaf_surname: Bartos - foaf_Person: foaf_givenName: Peter M foaf_name: Peter Jonas foaf_surname: Jonas foaf_workInfoHomepage: http://www.librecat.org/personId=353C1B58-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0001-5001-4804 bibo_doi: 10.1073/pnas.0910716107 bibo_issue: '2' bibo_volume: 107 dct_date: 2010^xs_gYear dct_publisher: National Academy of Sciences@ dct_title: Distinct nonuniform cable properties optimize rapid and efficient activation of fast-spiking GABAergic interneurons@ ...