---
res:
  bibo_abstract:
  - Can orthologous proteins differ in terms of their ability to be secreted? To answer
    this question, we investigated the distribution of signal peptides within the
    orthologous groups of Enterobacterales. Parsimony analysis and sequence comparisons
    revealed a large number of signal peptide gain and loss events, in which signal
    peptides emerge or disappear in the course of evolution. Signal peptide losses
    prevail over gains, an effect which is especially pronounced in the transition
    from the free-living or commensal to the endosymbiotic lifestyle. The disproportionate
    decline in the number of signal peptide-containing proteins in endosymbionts cannot
    be explained by the overall reduction of their genomes. Signal peptides can be
    gained and lost either by acquisition/elimination of the corresponding N-terminal
    regions or by gradual accumulation of mutations. The evolutionary dynamics of
    signal peptides in bacterial proteins represents a powerful mechanism of functional
    diversification.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Peter
      foaf_name: Hönigschmid, Peter
      foaf_surname: Hönigschmid
  - foaf_Person:
      foaf_givenName: Nadya
      foaf_name: Bykova, Nadya
      foaf_surname: Bykova
  - foaf_Person:
      foaf_givenName: René
      foaf_name: Schneider, René
      foaf_surname: Schneider
  - foaf_Person:
      foaf_givenName: Dmitry
      foaf_name: Ivankov, Dmitry
      foaf_surname: Ivankov
      foaf_workInfoHomepage: http://www.librecat.org/personId=49FF1036-F248-11E8-B48F-1D18A9856A87
  - foaf_Person:
      foaf_givenName: Dmitrij
      foaf_name: Frishman, Dmitrij
      foaf_surname: Frishman
  bibo_doi: 10.1093/gbe/evy049
  bibo_issue: '3'
  bibo_volume: 10
  dct_date: 2018^xs_gYear
  dct_identifier:
  - UT:000429483700022
  dct_language: eng
  dct_publisher: Oxford University Press@
  dct_title: Evolutionary interplay between symbiotic relationships and patterns of
    signal peptide gain and loss@
...