---
_id: '384'
abstract:
- lang: eng
  text: Can orthologous proteins differ in terms of their ability to be secreted?
    To answer this question, we investigated the distribution of signal peptides within
    the orthologous groups of Enterobacterales. Parsimony analysis and sequence comparisons
    revealed a large number of signal peptide gain and loss events, in which signal
    peptides emerge or disappear in the course of evolution. Signal peptide losses
    prevail over gains, an effect which is especially pronounced in the transition
    from the free-living or commensal to the endosymbiotic lifestyle. The disproportionate
    decline in the number of signal peptide-containing proteins in endosymbionts cannot
    be explained by the overall reduction of their genomes. Signal peptides can be
    gained and lost either by acquisition/elimination of the corresponding N-terminal
    regions or by gradual accumulation of mutations. The evolutionary dynamics of
    signal peptides in bacterial proteins represents a powerful mechanism of functional
    diversification.
acknowledgement: "his work was supported by the Deutsche Forschungsgemeinschaft  (grant
  \ number  FR  1411/9-1).  This work  was  supported  by  the  German  Research  Foundation
  (DFG) and the Technical University of Munich within the fund- ing programme Open
  Access Publish\r\nWe thank Goar Frishman for help with the annotation of the\r\nsymbiont
  status of the organisms and Michael Galperin for\r\nuseful comments. T"
article_processing_charge: No
author:
- first_name: Peter
  full_name: Hönigschmid, Peter
  last_name: Hönigschmid
- first_name: Nadya
  full_name: Bykova, Nadya
  last_name: Bykova
- first_name: René
  full_name: Schneider, René
  last_name: Schneider
- first_name: Dmitry
  full_name: Ivankov, Dmitry
  id: 49FF1036-F248-11E8-B48F-1D18A9856A87
  last_name: Ivankov
- first_name: Dmitrij
  full_name: Frishman, Dmitrij
  last_name: Frishman
citation:
  ama: Hönigschmid P, Bykova N, Schneider R, Ivankov D, Frishman D. Evolutionary interplay
    between symbiotic relationships and patterns of signal peptide gain and loss.
    <i>Genome Biology and Evolution</i>. 2018;10(3):928-938. doi:<a href="https://doi.org/10.1093/gbe/evy049">10.1093/gbe/evy049</a>
  apa: Hönigschmid, P., Bykova, N., Schneider, R., Ivankov, D., &#38; Frishman, D.
    (2018). Evolutionary interplay between symbiotic relationships and patterns of
    signal peptide gain and loss. <i>Genome Biology and Evolution</i>. Oxford University
    Press. <a href="https://doi.org/10.1093/gbe/evy049">https://doi.org/10.1093/gbe/evy049</a>
  chicago: Hönigschmid, Peter, Nadya Bykova, René Schneider, Dmitry Ivankov, and Dmitrij
    Frishman. “Evolutionary Interplay between Symbiotic Relationships and Patterns
    of Signal Peptide Gain and Loss.” <i>Genome Biology and Evolution</i>. Oxford
    University Press, 2018. <a href="https://doi.org/10.1093/gbe/evy049">https://doi.org/10.1093/gbe/evy049</a>.
  ieee: P. Hönigschmid, N. Bykova, R. Schneider, D. Ivankov, and D. Frishman, “Evolutionary
    interplay between symbiotic relationships and patterns of signal peptide gain
    and loss,” <i>Genome Biology and Evolution</i>, vol. 10, no. 3. Oxford University
    Press, pp. 928–938, 2018.
  ista: Hönigschmid P, Bykova N, Schneider R, Ivankov D, Frishman D. 2018. Evolutionary
    interplay between symbiotic relationships and patterns of signal peptide gain
    and loss. Genome Biology and Evolution. 10(3), 928–938.
  mla: Hönigschmid, Peter, et al. “Evolutionary Interplay between Symbiotic Relationships
    and Patterns of Signal Peptide Gain and Loss.” <i>Genome Biology and Evolution</i>,
    vol. 10, no. 3, Oxford University Press, 2018, pp. 928–38, doi:<a href="https://doi.org/10.1093/gbe/evy049">10.1093/gbe/evy049</a>.
  short: P. Hönigschmid, N. Bykova, R. Schneider, D. Ivankov, D. Frishman, Genome
    Biology and Evolution 10 (2018) 928–938.
date_created: 2018-12-11T11:46:10Z
date_published: 2018-03-01T00:00:00Z
date_updated: 2023-09-11T13:56:52Z
day: '01'
ddc:
- '576'
department:
- _id: FyKo
doi: 10.1093/gbe/evy049
external_id:
  isi:
  - '000429483700022'
file:
- access_level: open_access
  checksum: 458a7c2c2e79528567edfeb0f326cbe0
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:08:07Z
  date_updated: 2020-07-14T12:46:16Z
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  file_name: IST-2018-999-v1+1_2018_Ivankov_Evolutionary_interplay.pdf
  file_size: 691602
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file_date_updated: 2020-07-14T12:46:16Z
has_accepted_license: '1'
intvolume: '        10'
isi: 1
issue: '3'
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '03'
oa: 1
oa_version: Published Version
page: 928 - 938
publication: Genome Biology and Evolution
publication_status: published
publisher: Oxford University Press
publist_id: '7445'
pubrep_id: '999'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Evolutionary interplay between symbiotic relationships and patterns of signal
  peptide gain and loss
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 10
year: '2018'
...