[{"abstract":[{"lang":"eng"}],"issue":"6","type":"journal_article","file":[{"creator":"system","file_size":222890,"content_type":"application/pdf","access_level":"open_access","file_name":"IST-2012-66-v1+1_Fast_adaptive_uniformization_of_the_chemical_master_equation.pdf","checksum":"9a3bde48f43203991a0b3c6a277c2f5b","date_updated":"2020-07-14T12:46:16Z","date_created":"2018-12-12T10:17:02Z","file_id":"5254","relation":"main_file"}],"oa_version":"Submitted Version","pubrep_id":"66","ddc":[],"status":"public","intvolume":" 4","user_id":"4435EBFC-F248-11E8-B48F-1D18A9856A87","_id":"3842","day":"15","has_accepted_license":"1","uri_base":"https://research-explorer.ista.ac.at","scopus_import":1,"dc":{"title":["Fast adaptive uniformization of the chemical master equation"],"publisher":["Institution of Engineering and Technology"],"relation":["info:eu-repo/semantics/altIdentifier/doi/10.1049/iet-syb.2010.0005"],"subject":["ddc:570"],"source":["Didier F, Henzinger TA, Mateescu M, Wolf V. Fast adaptive uniformization of the chemical master equation. IET Systems Biology. 2010;4(6):441-452. doi:10.1049/iet-syb.2010.0005"],"rights":["info:eu-repo/semantics/openAccess"],"language":["eng"],"date":["2010"],"description":["Within systems biology there is an increasing interest in the stochastic behavior of biochemical reaction networks. An appropriate stochastic description is provided by the chemical master equation, which represents a continuous-time Markov chain (CTMC). The uniformization technique is an efficient method to compute probability distributions of a CTMC if the number of states is manageable. However, the size of a CTMC that represents a biochemical reaction network is usually far beyond what is feasible. In this paper we present an on-the-fly variant of uniformization, where we improve the original algorithm at the cost of a small approximation error. By means of several examples, we show that our approach is particularly well-suited for biochemical reaction networks."],"identifier":["https://research-explorer.ista.ac.at/record/3842","https://research-explorer.ista.ac.at/download/3842/5254"],"type":["info:eu-repo/semantics/article","doc-type:article","text","http://purl.org/coar/resource_type/c_6501"],"creator":["Didier, Frédéric","Henzinger, Thomas A","Mateescu, Maria","Wolf, Verena"]},"date_published":"2010-11-15T00:00:00Z","page":"441 - 452","publication":"IET Systems Biology","citation":{"mla":"Didier, Frédéric, et al. “Fast Adaptive Uniformization of the Chemical Master Equation.” IET Systems Biology, vol. 4, no. 6, Institution of Engineering and Technology, 2010, pp. 441–52, doi:10.1049/iet-syb.2010.0005.","short":"F. Didier, T.A. Henzinger, M. Mateescu, V. Wolf, IET Systems Biology 4 (2010) 441–452.","chicago":"Didier, Frédéric, Thomas A Henzinger, Maria Mateescu, and Verena Wolf. “Fast Adaptive Uniformization of the Chemical Master Equation.” IET Systems Biology. Institution of Engineering and Technology, 2010. https://doi.org/10.1049/iet-syb.2010.0005.","ista":"Didier F, Henzinger TA, Mateescu M, Wolf V. 2010. Fast adaptive uniformization of the chemical master equation. IET Systems Biology. 4(6), 441–452.","ieee":"F. Didier, T. A. Henzinger, M. Mateescu, and V. Wolf, “Fast adaptive uniformization of the chemical master equation,” IET Systems Biology, vol. 4, no. 6. Institution of Engineering and Technology, pp. 441–452, 2010.","apa":"Didier, F., Henzinger, T. A., Mateescu, M., & Wolf, V. (2010). Fast adaptive uniformization of the chemical master equation. IET Systems Biology. Institution of Engineering and Technology. https://doi.org/10.1049/iet-syb.2010.0005"},"creator":{"id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","login":"dernst"},"file_date_updated":"2020-07-14T12:46:16Z","publist_id":"2349","date_created":"2018-12-11T12:05:28Z","dini_type":"doc-type:article","date_updated":"2023-02-23T11:45:08Z","volume":4,"author":[{"first_name":"Frédéric","last_name":"Didier"},{"id":"40876CD8-F248-11E8-B48F-1D18A9856A87","orcid":"0000−0002−2985−7724","first_name":"Thomas A","last_name":"Henzinger"},{"last_name":"Mateescu","first_name":"Maria"},{"last_name":"Wolf","first_name":"Verena"}],"related_material":{"record":[{"status":"public","relation":"earlier_version","id":"3843"}]},"publication_status":"published","department":[{"tree":[{"_id":"ResearchGroups"},{"_id":"IST"}],"_id":"ToHe"}],"month":"11","language":[{}],"quality_controlled":"1","oa":1}]