---
res:
  bibo_abstract:
  - 'An active involvement of blood-brain barrier endothelial cell basement membranes
    in development of inflammatory lesions in the central nervous system (CNS) has
    not been considered to date. Here we investigated the molecular composition and
    possible function of the extracellular matrix encountered by extravasating T lymphocytes
    during experimental autoimmune encephalomyelitis (EAE). Endothelial basement membranes
    contained laminin 8 (alpha4beta1gamma1) and/or 10 (alpha5beta1gamma1) and their
    expression was influenced by proinflammatory cytokines or angiostatic agents.
    T cells emigrating into the CNS during EAE encountered two biochemically distinct
    basement membranes, the endothelial (containing laminins 8 and 10) and the parenchymal
    (containing laminins 1 and 2) basement membranes. However, inflammatory cuffs
    occurred exclusively around endothelial basement membranes containing laminin
    8, whereas in the presence of laminin 10 no infiltration was detectable. In vitro
    assays using encephalitogenic T cell lines revealed adhesion to laminins 8 and
    10, whereas binding to laminins 1 and 2 could not be induced. Downregulation of
    integrin alpha6 on cerebral endothelium at sites of T cell infiltration, plus
    a high turnover of laminin 8 at these sites, suggested two possible roles for
    laminin 8 in the endothelial basement membrane: one at the level of the endothelial
    cells resulting in reduced adhesion and, thereby, increased penetrability of the
    monolayer; and secondly at the level of the T cells providing direct signals to
    the transmigrating cells.@eng'
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Michael K
      foaf_name: Sixt, Michael K
      foaf_surname: Sixt
      foaf_workInfoHomepage: http://www.librecat.org/personId=41E9FBEA-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-6620-9179
  - foaf_Person:
      foaf_givenName: Britta
      foaf_name: Engelhardt, Britta
      foaf_surname: Engelhardt
  - foaf_Person:
      foaf_givenName: Friederike
      foaf_name: Pausch, Friederike
      foaf_surname: Pausch
  - foaf_Person:
      foaf_givenName: Rupert
      foaf_name: Hallmann, Rupert
      foaf_surname: Hallmann
  - foaf_Person:
      foaf_givenName: Olaf
      foaf_name: Wendler, Olaf
      foaf_surname: Wendler
  - foaf_Person:
      foaf_givenName: Lydia
      foaf_name: Sorokin, Lydia
      foaf_surname: Sorokin
  bibo_doi: '10.1083/jcb.153.5.933 '
  bibo_issue: '5'
  bibo_volume: 153
  dct_date: 2001^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/0021-9525
  dct_language: eng
  dct_publisher: Rockefeller University Press@
  dct_title: Endothelial cell laminin isoforms, laminins 8 and 10, play decisive roles
    in T cell recruitment across the blood-brain barrier in experimental autoimmune
    encephalomyelitis@
  fabio_hasPubmedId: '11381080'
...