---
_id: '3937'
abstract:
- lang: eng
text: Lymphocyte motility in lymph nodes is regulated by chemokines, but the contribution
of integrins to this motility remains obscure. Here we examined lymphocyte migration
over CCR7-binding chemokines that 'decorate' lymph node stroma. In a shear-free
environment, surface-bound lymph node chemokines but not their soluble counterparts
promoted robust and sustained T lymphocyte motility. The chemokine CCL21 induced
compartmentalized clustering of the integrins LFA-1 and VLA-4 in motile lymphocytes,
but both integrins remained nonadhesive to ligands on lymphocytes, dendritic cells
and stroma. The application of shear stress to lymphocytes interacting with CCL21
and integrin ligands promoted robust integrin-mediated adhesion. Thus, lymph node
chemokines that promote motility and strongly activate lymphocyte integrins under
shear forces fail to stimulate stable integrin adhesiveness in extravascular shear-free
environments.
author:
- first_name: Eilon
full_name: Woolf, Eilon
last_name: Woolf
- first_name: Irina
full_name: Grigorova, Irina
last_name: Grigorova
- first_name: Adi
full_name: Sagiv, Adi
last_name: Sagiv
- first_name: Valentin
full_name: Grabovsky, Valentin
last_name: Grabovsky
- first_name: Sara
full_name: Feigelson, Sara W
last_name: Feigelson
- first_name: Ziv
full_name: Shulman, Ziv
last_name: Shulman
- first_name: Tanja
full_name: Hartmann, Tanja
last_name: Hartmann
- first_name: Michael K
full_name: Michael Sixt
id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
last_name: Sixt
orcid: 0000-0002-6620-9179
- first_name: Jason
full_name: Cyster, Jason G
last_name: Cyster
- first_name: Ronen
full_name: Alon, Ronen
last_name: Alon
citation:
ama: Woolf E, Grigorova I, Sagiv A, et al. Lymph node chemokines promote sustained
T lymphocyte motility without triggering stable integrin adhesiveness in the absence
of shear forces. Nature Immunology. 2007;8(10):1076-1085. doi:10.1038/ni1499
apa: Woolf, E., Grigorova, I., Sagiv, A., Grabovsky, V., Feigelson, S., Shulman,
Z., … Alon, R. (2007). Lymph node chemokines promote sustained T lymphocyte motility
without triggering stable integrin adhesiveness in the absence of shear forces.
Nature Immunology. Nature Publishing Group. https://doi.org/10.1038/ni1499
chicago: Woolf, Eilon, Irina Grigorova, Adi Sagiv, Valentin Grabovsky, Sara Feigelson,
Ziv Shulman, Tanja Hartmann, Michael K Sixt, Jason Cyster, and Ronen Alon. “Lymph
Node Chemokines Promote Sustained T Lymphocyte Motility without Triggering Stable
Integrin Adhesiveness in the Absence of Shear Forces.” Nature Immunology.
Nature Publishing Group, 2007. https://doi.org/10.1038/ni1499.
ieee: E. Woolf et al., “Lymph node chemokines promote sustained T lymphocyte
motility without triggering stable integrin adhesiveness in the absence of shear
forces,” Nature Immunology, vol. 8, no. 10. Nature Publishing Group, pp.
1076–1085, 2007.
ista: Woolf E, Grigorova I, Sagiv A, Grabovsky V, Feigelson S, Shulman Z, Hartmann
T, Sixt MK, Cyster J, Alon R. 2007. Lymph node chemokines promote sustained T
lymphocyte motility without triggering stable integrin adhesiveness in the absence
of shear forces. Nature Immunology. 8(10), 1076–1085.
mla: Woolf, Eilon, et al. “Lymph Node Chemokines Promote Sustained T Lymphocyte
Motility without Triggering Stable Integrin Adhesiveness in the Absence of Shear
Forces.” Nature Immunology, vol. 8, no. 10, Nature Publishing Group, 2007,
pp. 1076–85, doi:10.1038/ni1499.
short: E. Woolf, I. Grigorova, A. Sagiv, V. Grabovsky, S. Feigelson, Z. Shulman,
T. Hartmann, M.K. Sixt, J. Cyster, R. Alon, Nature Immunology 8 (2007) 1076–1085.
date_created: 2018-12-11T12:05:59Z
date_published: 2007-08-26T00:00:00Z
date_updated: 2021-01-12T07:53:19Z
day: '26'
doi: 10.1038/ni1499
extern: 1
intvolume: ' 8'
issue: '10'
month: '08'
page: 1076 - 1085
publication: Nature Immunology
publication_status: published
publisher: Nature Publishing Group
publist_id: '2189'
quality_controlled: 0
status: public
title: Lymph node chemokines promote sustained T lymphocyte motility without triggering
stable integrin adhesiveness in the absence of shear forces
type: journal_article
volume: 8
year: '2007'
...