---
res:
  bibo_abstract:
  - The leading front of a cell can either protrude as an actin-free membrane bleb
    that is inflated by actomyosin-driven contractile forces, or as an actin-rich
    pseudopodium, a site where polymerizing actin filaments push out the membrane.
    Pushing filaments can only cause the membrane to protrude if the expanding actin
    network experiences a retrograde counter-force, which is usually provided by transmembrane
    receptors of the integrin family. Here we show that chemotactic dendritic cells
    mechanically adapt to the adhesive properties of their substrate by switching
    between integrin-mediated and integrin-independent locomotion. We found that on
    engaging the integrin-actin clutch, actin polymerization was entirely turned into
    protrusion, whereas on disengagement actin underwent slippage and retrograde flow.
    Remarkably, accelerated retrograde flow was balanced by an increased actin polymerization
    rate; therefore, cell shape and protrusion velocity remained constant on alternating
    substrates. Due to this adaptive response in polymerization dynamics, tracks of
    adhesive substrate did not dictate the path of the cells. Instead, directional
    guidance was exclusively provided by a soluble gradient of chemoattractant, which
    endowed these 'amoeboid' cells with extraordinary flexibility, enabling them to
    traverse almost every type of tissue.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Jörg
      foaf_name: Renkawitz, Jörg
      foaf_surname: Renkawitz
      foaf_workInfoHomepage: http://www.librecat.org/personId=3F0587C8-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0003-2856-3369
  - foaf_Person:
      foaf_givenName: Kathrin
      foaf_name: Schumann, Kathrin
      foaf_surname: Schumann
      foaf_workInfoHomepage: http://www.librecat.org/personId=F44D762E-4F9D-11E9-B64C-9EB26CEFFB5F
  - foaf_Person:
      foaf_givenName: Michele
      foaf_name: Weber, Michele
      foaf_surname: Weber
      foaf_workInfoHomepage: http://www.librecat.org/personId=3A3FC708-F248-11E8-B48F-1D18A9856A87
  - foaf_Person:
      foaf_givenName: Tim
      foaf_name: Lämmermann, Tim
      foaf_surname: Lämmermann
  - foaf_Person:
      foaf_givenName: Holger
      foaf_name: Pflicke, Holger
      foaf_surname: Pflicke
  - foaf_Person:
      foaf_givenName: Matthieu
      foaf_name: Piel, Matthieu
      foaf_surname: Piel
  - foaf_Person:
      foaf_givenName: Julien
      foaf_name: Polleux, Julien
      foaf_surname: Polleux
  - foaf_Person:
      foaf_givenName: Joachim
      foaf_name: Spatz, Joachim
      foaf_surname: Spatz
  - foaf_Person:
      foaf_givenName: Michael K
      foaf_name: Sixt, Michael K
      foaf_surname: Sixt
      foaf_workInfoHomepage: http://www.librecat.org/personId=41E9FBEA-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-6620-9179
  bibo_doi: 10.1038/ncb1992
  bibo_issue: '12'
  bibo_volume: 11
  dct_date: 2009^xs_gYear
  dct_language: eng
  dct_publisher: Nature Publishing Group@
  dct_title: Adaptive force transmission in amoeboid cell migration@
...