---
_id: '3958'
abstract:
- lang: eng
text: Extracellular matrix (ECM) proteins can modify immune reactions, e.g. by sequestering
or displaying growth factors and by interacting with immune and glial cells. Here
we quantified by quantitative polymerase chain reaction (qPCR) expression of 50
ECM components and 34 ECM degrading enzymes in multiple sclerosis (MS) active
and inactive white matter lesions. COL1A1, COL3A1, COL5A1 and COL5A2 chains were
induced strongly in active lesions and even more in inactive lesions. These chains
interact to form collagen types I, III and V, which are fibrillar collagens. Biglycan
and decorin, which can decorate fibrillar collagens, were also induced strongly.
The fibrillar collagens, biglycan and decorin were largely found between the endothelium
and astrocytic glia limitans in the perivascular space where they formed a meshwork
which was closely associated with infiltrating immune cells. In active lesions
collagen V was also seen in the heavily infiltrated parenchyma. Fibrillar collagens
I and III inhibited in vitro human monocyte production of CCL2 (MCP-1), an inflammatory
chemokine involved in recruitment of immune cells. Together, ECM changes in lesions
with different activities were quantified and proteins forming a perivascular
fibrosis were identified. Induced fibrillar collagens may contribute to limiting
enlargement of MS lesions by inhibiting the production of CCL2 by monocytes.
author:
- first_name: Hema
full_name: Mohan, Hema
last_name: Mohan
- first_name: Markus
full_name: Krumbholz, Markus
last_name: Krumbholz
- first_name: Rakhi
full_name: Sharma, Rakhi
last_name: Sharma
- first_name: Sylvia
full_name: Eisele, Sylvia
last_name: Eisele
- first_name: Andreas
full_name: Junker, Andreas
last_name: Junker
- first_name: Michael K
full_name: Michael Sixt
id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
last_name: Sixt
orcid: 0000-0002-6620-9179
- first_name: Jia
full_name: Newcombe, Jia
last_name: Newcombe
- first_name: Hartmut
full_name: Wekerle, Hartmut
last_name: Wekerle
- first_name: Reinhard
full_name: Hohlfeld, Reinhard
last_name: Hohlfeld
- first_name: Hans
full_name: Lassmann, Hans
last_name: Lassmann
- first_name: Edgar
full_name: Meinl, Edgar
last_name: Meinl
citation:
ama: 'Mohan H, Krumbholz M, Sharma R, et al. Extracellular matrix in multiple sclerosis
lesions: fibrillar collagens, biglycan and decorin are upregulated and associated
with infiltrating immune cells. Brain Pathology. 2010;20(5):966-975. doi:10.1111/j.1750-3639.2010.00399.x'
apa: 'Mohan, H., Krumbholz, M., Sharma, R., Eisele, S., Junker, A., Sixt, M. K.,
… Meinl, E. (2010). Extracellular matrix in multiple sclerosis lesions: fibrillar
collagens, biglycan and decorin are upregulated and associated with infiltrating
immune cells. Brain Pathology. Wiley-Blackwell. https://doi.org/10.1111/j.1750-3639.2010.00399.x'
chicago: 'Mohan, Hema, Markus Krumbholz, Rakhi Sharma, Sylvia Eisele, Andreas Junker,
Michael K Sixt, Jia Newcombe, et al. “Extracellular Matrix in Multiple Sclerosis
Lesions: Fibrillar Collagens, Biglycan and Decorin Are Upregulated and Associated
with Infiltrating Immune Cells.” Brain Pathology. Wiley-Blackwell, 2010.
https://doi.org/10.1111/j.1750-3639.2010.00399.x.'
ieee: 'H. Mohan et al., “Extracellular matrix in multiple sclerosis lesions:
fibrillar collagens, biglycan and decorin are upregulated and associated with
infiltrating immune cells,” Brain Pathology, vol. 20, no. 5. Wiley-Blackwell,
pp. 966–975, 2010.'
ista: 'Mohan H, Krumbholz M, Sharma R, Eisele S, Junker A, Sixt MK, Newcombe J,
Wekerle H, Hohlfeld R, Lassmann H, Meinl E. 2010. Extracellular matrix in multiple
sclerosis lesions: fibrillar collagens, biglycan and decorin are upregulated and
associated with infiltrating immune cells. Brain Pathology. 20(5), 966–975.'
mla: 'Mohan, Hema, et al. “Extracellular Matrix in Multiple Sclerosis Lesions: Fibrillar
Collagens, Biglycan and Decorin Are Upregulated and Associated with Infiltrating
Immune Cells.” Brain Pathology, vol. 20, no. 5, Wiley-Blackwell, 2010,
pp. 966–75, doi:10.1111/j.1750-3639.2010.00399.x.'
short: H. Mohan, M. Krumbholz, R. Sharma, S. Eisele, A. Junker, M.K. Sixt, J. Newcombe,
H. Wekerle, R. Hohlfeld, H. Lassmann, E. Meinl, Brain Pathology 20 (2010) 966–975.
date_created: 2018-12-11T12:06:07Z
date_published: 2010-09-01T00:00:00Z
date_updated: 2021-01-12T07:53:28Z
day: '01'
doi: 10.1111/j.1750-3639.2010.00399.x
extern: 1
intvolume: ' 20'
issue: '5'
month: '09'
page: 966 - 975
publication: Brain Pathology
publication_status: published
publisher: Wiley-Blackwell
publist_id: '2169'
quality_controlled: 0
status: public
title: 'Extracellular matrix in multiple sclerosis lesions: fibrillar collagens, biglycan
and decorin are upregulated and associated with infiltrating immune cells'
type: journal_article
volume: 20
year: '2010'
...