--- _id: '3961' abstract: - lang: eng text: For innate and adaptive immune responses it is essential that inflammatory cells use quick and flexible locomotion strategies. Accordingly, most leukocytes can efficiently infiltrate and traverse almost every physiological or artificial environment. Here, we review how leukocytes might achieve this task mechanistically, and summarize recent findings on the principles of cytoskeletal force generation and transduction at the leading edge of leukocytes. We propose a model in which the cells switch between adhesion-receptor-mediated force transmission and locomotion modes that are based on cellular deformations, but independent of adhesion receptors. This plasticity in migration strategies allows leukocytes to adapt to the geometry and molecular composition of their environment. acknowledgement: We are grateful to Michele Weber for critical comments on the manuscript. Work in the laboratory of M.S. is supported by the German Research Foundation, the Peter Hans Hofschneider Foundation for Experimental Biomedicine and the Max Planck Society. J.R. is supported by a PhD fellowship of the Böhringer Ingelheim Fond. We thank Reinhard Fässler and Stefan Jentsch for their continuous support. author: - first_name: Jörg full_name: Jörg Renkawitz id: 3F0587C8-F248-11E8-B48F-1D18A9856A87 last_name: Renkawitz orcid: 0000-0003-2856-3369 - first_name: Michael K full_name: Michael Sixt id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87 last_name: Sixt orcid: 0000-0002-6620-9179 citation: ama: Renkawitz J, Sixt MK. Mechanisms of force generation and force transmission during interstitial leukocyte migration. EMBO Reports. 2010;11(10):744-750. doi:10.1038/embor.2010.147 apa: Renkawitz, J., & Sixt, M. K. (2010). Mechanisms of force generation and force transmission during interstitial leukocyte migration. EMBO Reports. Wiley-Blackwell. https://doi.org/10.1038/embor.2010.147 chicago: Renkawitz, Jörg, and Michael K Sixt. “Mechanisms of Force Generation and Force Transmission during Interstitial Leukocyte Migration.” EMBO Reports. Wiley-Blackwell, 2010. https://doi.org/10.1038/embor.2010.147. ieee: J. Renkawitz and M. K. Sixt, “Mechanisms of force generation and force transmission during interstitial leukocyte migration,” EMBO Reports, vol. 11, no. 10. Wiley-Blackwell, pp. 744–750, 2010. ista: Renkawitz J, Sixt MK. 2010. Mechanisms of force generation and force transmission during interstitial leukocyte migration. EMBO Reports. 11(10), 744–750. mla: Renkawitz, Jörg, and Michael K. Sixt. “Mechanisms of Force Generation and Force Transmission during Interstitial Leukocyte Migration.” EMBO Reports, vol. 11, no. 10, Wiley-Blackwell, 2010, pp. 744–50, doi:10.1038/embor.2010.147. short: J. Renkawitz, M.K. Sixt, EMBO Reports 11 (2010) 744–750. date_created: 2018-12-11T12:06:08Z date_published: 2010-09-24T00:00:00Z date_updated: 2021-01-12T07:53:30Z day: '24' doi: 10.1038/embor.2010.147 extern: 1 intvolume: ' 11' issue: '10' month: '09' page: 744 - 750 publication: EMBO Reports publication_status: published publisher: Wiley-Blackwell publist_id: '2166' quality_controlled: 0 status: public title: Mechanisms of force generation and force transmission during interstitial leukocyte migration type: journal_article volume: 11 year: '2010' ...