---
_id: '3961'
abstract:
- lang: eng
text: For innate and adaptive immune responses it is essential that inflammatory
cells use quick and flexible locomotion strategies. Accordingly, most leukocytes
can efficiently infiltrate and traverse almost every physiological or artificial
environment. Here, we review how leukocytes might achieve this task mechanistically,
and summarize recent findings on the principles of cytoskeletal force generation
and transduction at the leading edge of leukocytes. We propose a model in which
the cells switch between adhesion-receptor-mediated force transmission and locomotion
modes that are based on cellular deformations, but independent of adhesion receptors.
This plasticity in migration strategies allows leukocytes to adapt to the geometry
and molecular composition of their environment.
acknowledgement: We are grateful to Michele Weber for critical comments on the manuscript.
Work in the laboratory of M.S. is supported by the German Research Foundation, the
Peter Hans Hofschneider Foundation for Experimental Biomedicine and the Max Planck
Society. J.R. is supported by a PhD fellowship of the Böhringer Ingelheim Fond.
We thank Reinhard Fässler and Stefan Jentsch for their continuous support.
author:
- first_name: Jörg
full_name: Jörg Renkawitz
id: 3F0587C8-F248-11E8-B48F-1D18A9856A87
last_name: Renkawitz
orcid: 0000-0003-2856-3369
- first_name: Michael K
full_name: Michael Sixt
id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
last_name: Sixt
orcid: 0000-0002-6620-9179
citation:
ama: Renkawitz J, Sixt MK. Mechanisms of force generation and force transmission
during interstitial leukocyte migration. EMBO Reports. 2010;11(10):744-750.
doi:10.1038/embor.2010.147
apa: Renkawitz, J., & Sixt, M. K. (2010). Mechanisms of force generation and
force transmission during interstitial leukocyte migration. EMBO Reports.
Wiley-Blackwell. https://doi.org/10.1038/embor.2010.147
chicago: Renkawitz, Jörg, and Michael K Sixt. “Mechanisms of Force Generation and
Force Transmission during Interstitial Leukocyte Migration.” EMBO Reports.
Wiley-Blackwell, 2010. https://doi.org/10.1038/embor.2010.147.
ieee: J. Renkawitz and M. K. Sixt, “Mechanisms of force generation and force transmission
during interstitial leukocyte migration,” EMBO Reports, vol. 11, no. 10.
Wiley-Blackwell, pp. 744–750, 2010.
ista: Renkawitz J, Sixt MK. 2010. Mechanisms of force generation and force transmission
during interstitial leukocyte migration. EMBO Reports. 11(10), 744–750.
mla: Renkawitz, Jörg, and Michael K. Sixt. “Mechanisms of Force Generation and Force
Transmission during Interstitial Leukocyte Migration.” EMBO Reports, vol.
11, no. 10, Wiley-Blackwell, 2010, pp. 744–50, doi:10.1038/embor.2010.147.
short: J. Renkawitz, M.K. Sixt, EMBO Reports 11 (2010) 744–750.
date_created: 2018-12-11T12:06:08Z
date_published: 2010-09-24T00:00:00Z
date_updated: 2021-01-12T07:53:30Z
day: '24'
doi: 10.1038/embor.2010.147
extern: 1
intvolume: ' 11'
issue: '10'
month: '09'
page: 744 - 750
publication: EMBO Reports
publication_status: published
publisher: Wiley-Blackwell
publist_id: '2166'
quality_controlled: 0
status: public
title: Mechanisms of force generation and force transmission during interstitial leukocyte
migration
type: journal_article
volume: 11
year: '2010'
...