---
_id: '3961'
abstract:
- lang: eng
  text: For innate and adaptive immune responses it is essential that inflammatory
    cells use quick and flexible locomotion strategies. Accordingly, most leukocytes
    can efficiently infiltrate and traverse almost every physiological or artificial
    environment. Here, we review how leukocytes might achieve this task mechanistically,
    and summarize recent findings on the principles of cytoskeletal force generation
    and transduction at the leading edge of leukocytes. We propose a model in which
    the cells switch between adhesion-receptor-mediated force transmission and locomotion
    modes that are based on cellular deformations, but independent of adhesion receptors.
    This plasticity in migration strategies allows leukocytes to adapt to the geometry
    and molecular composition of their environment.
acknowledgement: We are grateful to Michele Weber for critical comments on the manuscript.
  Work in the laboratory of M.S. is supported by the German Research Foundation, the
  Peter Hans Hofschneider Foundation for Experimental Biomedicine and the Max Planck
  Society. J.R. is supported by a PhD fellowship of the Böhringer Ingelheim Fond.
  We thank Reinhard Fässler and Stefan Jentsch for their continuous support.
author:
- first_name: Jörg
  full_name: Jörg Renkawitz
  id: 3F0587C8-F248-11E8-B48F-1D18A9856A87
  last_name: Renkawitz
  orcid: 0000-0003-2856-3369
- first_name: Michael K
  full_name: Michael Sixt
  id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
  last_name: Sixt
  orcid: 0000-0002-6620-9179
citation:
  ama: Renkawitz J, Sixt MK. Mechanisms of force generation and force transmission
    during interstitial leukocyte migration. <i>EMBO Reports</i>. 2010;11(10):744-750.
    doi:<a href="https://doi.org/10.1038/embor.2010.147">10.1038/embor.2010.147</a>
  apa: Renkawitz, J., &#38; Sixt, M. K. (2010). Mechanisms of force generation and
    force transmission during interstitial leukocyte migration. <i>EMBO Reports</i>.
    Wiley-Blackwell. <a href="https://doi.org/10.1038/embor.2010.147">https://doi.org/10.1038/embor.2010.147</a>
  chicago: Renkawitz, Jörg, and Michael K Sixt. “Mechanisms of Force Generation and
    Force Transmission during Interstitial Leukocyte Migration.” <i>EMBO Reports</i>.
    Wiley-Blackwell, 2010. <a href="https://doi.org/10.1038/embor.2010.147">https://doi.org/10.1038/embor.2010.147</a>.
  ieee: J. Renkawitz and M. K. Sixt, “Mechanisms of force generation and force transmission
    during interstitial leukocyte migration,” <i>EMBO Reports</i>, vol. 11, no. 10.
    Wiley-Blackwell, pp. 744–750, 2010.
  ista: Renkawitz J, Sixt MK. 2010. Mechanisms of force generation and force transmission
    during interstitial leukocyte migration. EMBO Reports. 11(10), 744–750.
  mla: Renkawitz, Jörg, and Michael K. Sixt. “Mechanisms of Force Generation and Force
    Transmission during Interstitial Leukocyte Migration.” <i>EMBO Reports</i>, vol.
    11, no. 10, Wiley-Blackwell, 2010, pp. 744–50, doi:<a href="https://doi.org/10.1038/embor.2010.147">10.1038/embor.2010.147</a>.
  short: J. Renkawitz, M.K. Sixt, EMBO Reports 11 (2010) 744–750.
date_created: 2018-12-11T12:06:08Z
date_published: 2010-09-24T00:00:00Z
date_updated: 2021-01-12T07:53:30Z
day: '24'
doi: 10.1038/embor.2010.147
extern: 1
intvolume: '        11'
issue: '10'
month: '09'
page: 744 - 750
publication: EMBO Reports
publication_status: published
publisher: Wiley-Blackwell
publist_id: '2166'
quality_controlled: 0
status: public
title: Mechanisms of force generation and force transmission during interstitial leukocyte
  migration
type: journal_article
volume: 11
year: '2010'
...