@article{401, abstract = {The actomyosin cytoskeleton, a key stress-producing unit in epithelial cells, oscillates spontaneously in a wide variety of systems. Although much of the signal cascade regulating myosin activity has been characterized, the origin of such oscillatory behavior is still unclear. Here, we show that basal myosin II oscillation in Drosophila ovarian epithelium is not controlled by actomyosin cortical tension, but instead relies on a biochemical oscillator involving ROCK and myosin phosphatase. Key to this oscillation is a diffusive ROCK flow, linking junctional Rho1 to medial actomyosin cortex, and dynamically maintained by a self-activation loop reliant on ROCK kinase activity. In response to the resulting myosin II recruitment, myosin phosphatase is locally enriched and shuts off ROCK and myosin II signals. Coupling Drosophila genetics, live imaging, modeling, and optogenetics, we uncover an intrinsic biochemical oscillator at the core of myosin II regulatory network, shedding light on the spatio-temporal dynamics of force generation.}, author = {Qin, Xiang and Hannezo, Edouard B and Mangeat, Thomas and Liu, Chang and Majumder, Pralay and Liu, Jjiaying and Choesmel Cadamuro, Valerie and Mcdonald, Jocelyn and Liu, Yinyao and Yi, Bin and Wang, Xiaobo}, journal = {Nature Communications}, number = {1}, publisher = {Nature Publishing Group}, title = {{A biochemical network controlling basal myosin oscillation}}, doi = {10.1038/s41467-018-03574-5}, volume = {9}, year = {2018}, }