{"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)"},"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","month":"03","article_processing_charge":"No","ddc":["539","570"],"doi":"10.1038/s41467-018-03574-5","status":"public","issue":"1","language":[{"iso":"eng"}],"publication":"Nature Communications","external_id":{"isi":["000428165400009"]},"publisher":"Nature Publishing Group","author":[{"last_name":"Qin","first_name":"Xiang","full_name":"Qin, Xiang"},{"id":"3A9DB764-F248-11E8-B48F-1D18A9856A87","last_name":"Hannezo","first_name":"Edouard B","full_name":"Hannezo, Edouard B","orcid":"0000-0001-6005-1561"},{"first_name":"Thomas","last_name":"Mangeat","full_name":"Mangeat, Thomas"},{"last_name":"Liu","first_name":"Chang","full_name":"Liu, Chang"},{"first_name":"Pralay","last_name":"Majumder","full_name":"Majumder, Pralay"},{"full_name":"Liu, Jjiaying","first_name":"Jjiaying","last_name":"Liu"},{"first_name":"Valerie","last_name":"Choesmel Cadamuro","full_name":"Choesmel Cadamuro, Valerie"},{"last_name":"Mcdonald","first_name":"Jocelyn","full_name":"Mcdonald, Jocelyn"},{"full_name":"Liu, Yinyao","first_name":"Yinyao","last_name":"Liu"},{"last_name":"Yi","first_name":"Bin","full_name":"Yi, Bin"},{"full_name":"Wang, Xiaobo","first_name":"Xiaobo","last_name":"Wang"}],"date_created":"2018-12-11T11:46:16Z","year":"2018","publication_status":"published","intvolume":" 9","date_published":"2018-03-23T00:00:00Z","file_date_updated":"2020-07-14T12:46:22Z","type":"journal_article","quality_controlled":"1","has_accepted_license":"1","scopus_import":"1","department":[{"_id":"EdHa"}],"oa_version":"Published Version","citation":{"apa":"Qin, X., Hannezo, E. B., Mangeat, T., Liu, C., Majumder, P., Liu, J., … Wang, X. (2018). A biochemical network controlling basal myosin oscillation. Nature Communications. Nature Publishing Group. https://doi.org/10.1038/s41467-018-03574-5","ieee":"X. Qin et al., “A biochemical network controlling basal myosin oscillation,” Nature Communications, vol. 9, no. 1. Nature Publishing Group, 2018.","ista":"Qin X, Hannezo EB, Mangeat T, Liu C, Majumder P, Liu J, Choesmel Cadamuro V, Mcdonald J, Liu Y, Yi B, Wang X. 2018. A biochemical network controlling basal myosin oscillation. Nature Communications. 9(1), 1210.","chicago":"Qin, Xiang, Edouard B Hannezo, Thomas Mangeat, Chang Liu, Pralay Majumder, Jjiaying Liu, Valerie Choesmel Cadamuro, et al. “A Biochemical Network Controlling Basal Myosin Oscillation.” Nature Communications. Nature Publishing Group, 2018. https://doi.org/10.1038/s41467-018-03574-5.","short":"X. Qin, E.B. Hannezo, T. Mangeat, C. Liu, P. Majumder, J. Liu, V. Choesmel Cadamuro, J. Mcdonald, Y. Liu, B. Yi, X. Wang, Nature Communications 9 (2018).","ama":"Qin X, Hannezo EB, Mangeat T, et al. A biochemical network controlling basal myosin oscillation. Nature Communications. 2018;9(1). doi:10.1038/s41467-018-03574-5","mla":"Qin, Xiang, et al. “A Biochemical Network Controlling Basal Myosin Oscillation.” Nature Communications, vol. 9, no. 1, 1210, Nature Publishing Group, 2018, doi:10.1038/s41467-018-03574-5."},"day":"23","_id":"401","title":"A biochemical network controlling basal myosin oscillation","pubrep_id":"996","publist_id":"7427","article_number":"1210","oa":1,"abstract":[{"lang":"eng","text":"The actomyosin cytoskeleton, a key stress-producing unit in epithelial cells, oscillates spontaneously in a wide variety of systems. Although much of the signal cascade regulating myosin activity has been characterized, the origin of such oscillatory behavior is still unclear. Here, we show that basal myosin II oscillation in Drosophila ovarian epithelium is not controlled by actomyosin cortical tension, but instead relies on a biochemical oscillator involving ROCK and myosin phosphatase. Key to this oscillation is a diffusive ROCK flow, linking junctional Rho1 to medial actomyosin cortex, and dynamically maintained by a self-activation loop reliant on ROCK kinase activity. In response to the resulting myosin II recruitment, myosin phosphatase is locally enriched and shuts off ROCK and myosin II signals. Coupling Drosophila genetics, live imaging, modeling, and optogenetics, we uncover an intrinsic biochemical oscillator at the core of myosin II regulatory network, shedding light on the spatio-temporal dynamics of force generation."}],"date_updated":"2023-09-08T11:41:45Z","volume":9,"isi":1,"file":[{"relation":"main_file","access_level":"open_access","file_id":"4902","content_type":"application/pdf","date_created":"2018-12-12T10:11:45Z","date_updated":"2020-07-14T12:46:22Z","file_name":"IST-2018-996-v1+1_2018_Hannezo_A-biochemical.pdf","file_size":3780491,"creator":"system","checksum":"87a427bc2e8724be3dd22a4efdd21a33"}]}