---
res:
  bibo_abstract:
  - During metastasis, malignant cells escape the primary tumor, intravasate lymphatic
    vessels, and reach draining sentinel lymph nodes before they colonize distant
    organs via the blood circulation. Although lymph node metastasis in cancer patients
    correlates with poor prognosis, evidence is lacking as to whether and how tumor
    cells enter the bloodstream via lymph nodes. To investigate this question, we
    delivered carcinoma cells into the lymph nodes of mice by microinfusing the cells
    into afferent lymphatic vessels. We found that tumor cells rapidly infiltrated
    the lymph node parenchyma, invaded blood vessels, and seeded lung metastases without
    involvement of the thoracic duct. These results suggest that the lymph node blood
    vessels can serve as an exit route for systemic dissemination of cancer cells
    in experimental mouse models. Whether this form of tumor cell spreading occurs
    in cancer patients remains to be determined.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Markus
      foaf_name: Brown, Markus
      foaf_surname: Brown
      foaf_workInfoHomepage: http://www.librecat.org/personId=3DAB9AFC-F248-11E8-B48F-1D18A9856A87
  - foaf_Person:
      foaf_givenName: Frank P
      foaf_name: Assen, Frank P
      foaf_surname: Assen
      foaf_workInfoHomepage: http://www.librecat.org/personId=3A8E7F24-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0003-3470-6119
  - foaf_Person:
      foaf_givenName: Alexander F
      foaf_name: Leithner, Alexander F
      foaf_surname: Leithner
      foaf_workInfoHomepage: http://www.librecat.org/personId=3B1B77E4-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-1073-744X
  - foaf_Person:
      foaf_givenName: Jun
      foaf_name: Abe, Jun
      foaf_surname: Abe
  - foaf_Person:
      foaf_givenName: Helga
      foaf_name: Schachner, Helga
      foaf_surname: Schachner
  - foaf_Person:
      foaf_givenName: Gabriele
      foaf_name: Asfour, Gabriele
      foaf_surname: Asfour
  - foaf_Person:
      foaf_givenName: Zsuzsanna
      foaf_name: Bagó Horváth, Zsuzsanna
      foaf_surname: Bagó Horváth
  - foaf_Person:
      foaf_givenName: Jens
      foaf_name: Stein, Jens
      foaf_surname: Stein
  - foaf_Person:
      foaf_givenName: Pavel
      foaf_name: Uhrin, Pavel
      foaf_surname: Uhrin
  - foaf_Person:
      foaf_givenName: Michael K
      foaf_name: Sixt, Michael K
      foaf_surname: Sixt
      foaf_workInfoHomepage: http://www.librecat.org/personId=41E9FBEA-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-6620-9179
  - foaf_Person:
      foaf_givenName: Dontscho
      foaf_name: Kerjaschki, Dontscho
      foaf_surname: Kerjaschki
  bibo_doi: 10.1126/science.aal3662
  bibo_issue: '6382'
  bibo_volume: 359
  dct_date: 2018^xs_gYear
  dct_identifier:
  - UT:000428043600047
  dct_language: eng
  dct_publisher: American Association for the Advancement of Science@
  dct_title: Lymph node blood vessels provide exit routes for metastatic tumor cell
    dissemination in mice@
  fabio_hasPubmedId: '29567714'
...