---
_id: '4151'
abstract:
- lang: eng
text: 'Jaws and branchial arches together are a basic, segmented feature of the
vertebrate head, Seven arches develop in the zebrafish embryo (Danio rerio), derived
largely from neural crest cells that form the cartilaginous skeleton, In this
and the following paper we describe the phenotypes of 109 arch mutants, focusing
here on three classes that affect the posterior pharyngeal arches, including the
hyoid and five gill-bearing arches, In lockjaw, the hyoid arch is strongly reduced
and subsets of branchial arches do not develop, Mutants of a large second class,
designated the flathead group, lack several adjacent branchial arches and their
associated cartilages. Five alleles at the flathead locus all lead to larvae that
lack arches 4-6, Among 34 other flathead group members complementation tests are
incomplete, but at least six unique phenotypes can be distinguished, These all
delete continuous stretches of adjacent branchial arches and unpaired cartilages
in the ventral midline, Many show cell death in the midbrain, from which some
neural crest precursors of the arches originate, lockjaw and a few mutants in
the flathead group, including pistachio, affect both jaw cartilage and pigmentation,
reflecting essential functions of these genes in at least two neural crest lineages,
Mutants of a third class, including boxer, dackel and pincher, affect pectoral
fins and axonal trajectories in the brain, as well as the arches. Their skeletal
phenotypes suggest that they disrupt cartilage morphogenesis in all arches, Our
results suggest that there are sets of genes that: (1) specify neural crest cells
in groups of adjacent head segments, and (2) function in common genetic pathways
in a variety of tissues including the brain, pectoral fins and pigment cells as
well as pharyngeal arches.'
acknowledgement: We thank Drs Charles Kimmel, Philip Ingham, Paula Mabee and members
of the Ingham lab for critical comments on the manuscript.
article_processing_charge: No
article_type: original
author:
- first_name: Thomas
full_name: Schilling, Thomas
last_name: Schilling
- first_name: Tatjana
full_name: Piotrowski, Tatjana
last_name: Piotrowski
- first_name: Heiner
full_name: Grandel, Heiner
last_name: Grandel
- first_name: Michael
full_name: Brand, Michael
last_name: Brand
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Yunjin
full_name: Jiang, Yunjin
last_name: Jiang
- first_name: Dirk
full_name: Beuchle, Dirk
last_name: Beuchle
- first_name: Matthias
full_name: Hammerschmidt, Matthias
last_name: Hammerschmidt
- first_name: Donald
full_name: Kane, Donald
last_name: Kane
- first_name: Mary
full_name: Mullins, Mary
last_name: Mullins
- first_name: Fredericus
full_name: Van Eeden, Fredericus
last_name: Van Eeden
- first_name: Robert
full_name: Kelsh, Robert
last_name: Kelsh
- first_name: Makoto
full_name: Furutani Seiki, Makoto
last_name: Furutani Seiki
- first_name: Michael
full_name: Granato, Michael
last_name: Granato
- first_name: Pascal
full_name: Haffter, Pascal
last_name: Haffter
- first_name: Jörg
full_name: Odenthal, Jörg
last_name: Odenthal
- first_name: Rachel
full_name: Warga, Rachel
last_name: Warga
- first_name: Torsten
full_name: Trowe, Torsten
last_name: Trowe
- first_name: Christiane
full_name: Nüsslein Volhard, Christiane
last_name: Nüsslein Volhard
citation:
ama: 'Schilling T, Piotrowski T, Grandel H, et al. Jaw and branchial arch mutants
in zebrafish I: Branchial arches. Development. 1996;123(1):329-344. doi:10.1242/dev.123.1.329'
apa: 'Schilling, T., Piotrowski, T., Grandel, H., Brand, M., Heisenberg, C.-P. J.,
Jiang, Y., … Nüsslein Volhard, C. (1996). Jaw and branchial arch mutants in zebrafish
I: Branchial arches. Development. Company of Biologists. https://doi.org/10.1242/dev.123.1.329'
chicago: 'Schilling, Thomas, Tatjana Piotrowski, Heiner Grandel, Michael Brand,
Carl-Philipp J Heisenberg, Yunjin Jiang, Dirk Beuchle, et al. “Jaw and Branchial
Arch Mutants in Zebrafish I: Branchial Arches.” Development. Company of
Biologists, 1996. https://doi.org/10.1242/dev.123.1.329.'
ieee: 'T. Schilling et al., “Jaw and branchial arch mutants in zebrafish
I: Branchial arches,” Development, vol. 123, no. 1. Company of Biologists,
pp. 329–344, 1996.'
ista: 'Schilling T, Piotrowski T, Grandel H, Brand M, Heisenberg C-PJ, Jiang Y,
Beuchle D, Hammerschmidt M, Kane D, Mullins M, Van Eeden F, Kelsh R, Furutani
Seiki M, Granato M, Haffter P, Odenthal J, Warga R, Trowe T, Nüsslein Volhard
C. 1996. Jaw and branchial arch mutants in zebrafish I: Branchial arches. Development.
123(1), 329–344.'
mla: 'Schilling, Thomas, et al. “Jaw and Branchial Arch Mutants in Zebrafish I:
Branchial Arches.” Development, vol. 123, no. 1, Company of Biologists,
1996, pp. 329–44, doi:10.1242/dev.123.1.329.'
short: T. Schilling, T. Piotrowski, H. Grandel, M. Brand, C.-P.J. Heisenberg, Y.
Jiang, D. Beuchle, M. Hammerschmidt, D. Kane, M. Mullins, F. Van Eeden, R. Kelsh,
M. Furutani Seiki, M. Granato, P. Haffter, J. Odenthal, R. Warga, T. Trowe, C.
Nüsslein Volhard, Development 123 (1996) 329–344.
date_created: 2018-12-11T12:07:15Z
date_published: 1996-12-01T00:00:00Z
date_updated: 2022-08-08T08:41:00Z
day: '01'
doi: 10.1242/dev.123.1.329
extern: '1'
external_id:
pmid:
- '9007253'
intvolume: ' 123'
issue: '1'
language:
- iso: eng
month: '12'
oa_version: None
page: 329 - 344
pmid: 1
publication: Development
publication_identifier:
issn:
- 0950-1991
publication_status: published
publisher: Company of Biologists
publist_id: '1968'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Jaw and branchial arch mutants in zebrafish I: Branchial arches'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 123
year: '1996'
...