--- _id: '4151' abstract: - lang: eng text: 'Jaws and branchial arches together are a basic, segmented feature of the vertebrate head, Seven arches develop in the zebrafish embryo (Danio rerio), derived largely from neural crest cells that form the cartilaginous skeleton, In this and the following paper we describe the phenotypes of 109 arch mutants, focusing here on three classes that affect the posterior pharyngeal arches, including the hyoid and five gill-bearing arches, In lockjaw, the hyoid arch is strongly reduced and subsets of branchial arches do not develop, Mutants of a large second class, designated the flathead group, lack several adjacent branchial arches and their associated cartilages. Five alleles at the flathead locus all lead to larvae that lack arches 4-6, Among 34 other flathead group members complementation tests are incomplete, but at least six unique phenotypes can be distinguished, These all delete continuous stretches of adjacent branchial arches and unpaired cartilages in the ventral midline, Many show cell death in the midbrain, from which some neural crest precursors of the arches originate, lockjaw and a few mutants in the flathead group, including pistachio, affect both jaw cartilage and pigmentation, reflecting essential functions of these genes in at least two neural crest lineages, Mutants of a third class, including boxer, dackel and pincher, affect pectoral fins and axonal trajectories in the brain, as well as the arches. Their skeletal phenotypes suggest that they disrupt cartilage morphogenesis in all arches, Our results suggest that there are sets of genes that: (1) specify neural crest cells in groups of adjacent head segments, and (2) function in common genetic pathways in a variety of tissues including the brain, pectoral fins and pigment cells as well as pharyngeal arches.' acknowledgement: We thank Drs Charles Kimmel, Philip Ingham, Paula Mabee and members of the Ingham lab for critical comments on the manuscript. article_processing_charge: No article_type: original author: - first_name: Thomas full_name: Schilling, Thomas last_name: Schilling - first_name: Tatjana full_name: Piotrowski, Tatjana last_name: Piotrowski - first_name: Heiner full_name: Grandel, Heiner last_name: Grandel - first_name: Michael full_name: Brand, Michael last_name: Brand - first_name: Carl-Philipp J full_name: Heisenberg, Carl-Philipp J id: 39427864-F248-11E8-B48F-1D18A9856A87 last_name: Heisenberg orcid: 0000-0002-0912-4566 - first_name: Yunjin full_name: Jiang, Yunjin last_name: Jiang - first_name: Dirk full_name: Beuchle, Dirk last_name: Beuchle - first_name: Matthias full_name: Hammerschmidt, Matthias last_name: Hammerschmidt - first_name: Donald full_name: Kane, Donald last_name: Kane - first_name: Mary full_name: Mullins, Mary last_name: Mullins - first_name: Fredericus full_name: Van Eeden, Fredericus last_name: Van Eeden - first_name: Robert full_name: Kelsh, Robert last_name: Kelsh - first_name: Makoto full_name: Furutani Seiki, Makoto last_name: Furutani Seiki - first_name: Michael full_name: Granato, Michael last_name: Granato - first_name: Pascal full_name: Haffter, Pascal last_name: Haffter - first_name: Jörg full_name: Odenthal, Jörg last_name: Odenthal - first_name: Rachel full_name: Warga, Rachel last_name: Warga - first_name: Torsten full_name: Trowe, Torsten last_name: Trowe - first_name: Christiane full_name: Nüsslein Volhard, Christiane last_name: Nüsslein Volhard citation: ama: 'Schilling T, Piotrowski T, Grandel H, et al. Jaw and branchial arch mutants in zebrafish I: Branchial arches. Development. 1996;123(1):329-344. doi:10.1242/dev.123.1.329' apa: 'Schilling, T., Piotrowski, T., Grandel, H., Brand, M., Heisenberg, C.-P. J., Jiang, Y., … Nüsslein Volhard, C. (1996). Jaw and branchial arch mutants in zebrafish I: Branchial arches. Development. Company of Biologists. https://doi.org/10.1242/dev.123.1.329' chicago: 'Schilling, Thomas, Tatjana Piotrowski, Heiner Grandel, Michael Brand, Carl-Philipp J Heisenberg, Yunjin Jiang, Dirk Beuchle, et al. “Jaw and Branchial Arch Mutants in Zebrafish I: Branchial Arches.” Development. Company of Biologists, 1996. https://doi.org/10.1242/dev.123.1.329.' ieee: 'T. Schilling et al., “Jaw and branchial arch mutants in zebrafish I: Branchial arches,” Development, vol. 123, no. 1. Company of Biologists, pp. 329–344, 1996.' ista: 'Schilling T, Piotrowski T, Grandel H, Brand M, Heisenberg C-PJ, Jiang Y, Beuchle D, Hammerschmidt M, Kane D, Mullins M, Van Eeden F, Kelsh R, Furutani Seiki M, Granato M, Haffter P, Odenthal J, Warga R, Trowe T, Nüsslein Volhard C. 1996. Jaw and branchial arch mutants in zebrafish I: Branchial arches. Development. 123(1), 329–344.' mla: 'Schilling, Thomas, et al. “Jaw and Branchial Arch Mutants in Zebrafish I: Branchial Arches.” Development, vol. 123, no. 1, Company of Biologists, 1996, pp. 329–44, doi:10.1242/dev.123.1.329.' short: T. Schilling, T. Piotrowski, H. Grandel, M. Brand, C.-P.J. Heisenberg, Y. Jiang, D. Beuchle, M. Hammerschmidt, D. Kane, M. Mullins, F. Van Eeden, R. Kelsh, M. Furutani Seiki, M. Granato, P. Haffter, J. Odenthal, R. Warga, T. Trowe, C. Nüsslein Volhard, Development 123 (1996) 329–344. date_created: 2018-12-11T12:07:15Z date_published: 1996-12-01T00:00:00Z date_updated: 2022-08-08T08:41:00Z day: '01' doi: 10.1242/dev.123.1.329 extern: '1' external_id: pmid: - '9007253' intvolume: ' 123' issue: '1' language: - iso: eng month: '12' oa_version: None page: 329 - 344 pmid: 1 publication: Development publication_identifier: issn: - 0950-1991 publication_status: published publisher: Company of Biologists publist_id: '1968' quality_controlled: '1' scopus_import: '1' status: public title: 'Jaw and branchial arch mutants in zebrafish I: Branchial arches' type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 123 year: '1996' ...