@article{4179, abstract = {Neurotrophin-3 (NT-3) is a member of the neurotrophin gene family and is highly expressed in the developing rat cerebellum. Here we show that brain-derived neurotrophic factor (BDNF) increased by approximately 10-fold the NT-3 mRNA levels in cultured cerebellar granule neurons isolated from postnatal rats, whereas nerve growth factor (NGF) and NT-3 itself had no effect. The effect of BDNF was additive to that of triiodothyronine (T3), which also increased NT-3 mRNA in these neurons. The drug K252a inhibited the BDNF-mediated stimulation of NT-3 expression, suggesting an involvement of trkB receptors. Nuclear run-on experiments showed that BDNF enhanced NT-3 transcription, whereas the stability of NT-3 mRNA remained unchanged. The data presented are the first demonstration that one neurotrophin regulates the expression of another and provide evidence that NT-3 production in granule neurons is regulated by both BDNF and T3.}, author = {Leingärtner, Axel and Heisenberg, Carl-Philipp J and Kolbeck, Roland and Thoenen, Hans and Lindholm, Dan}, issn = {1083-351X}, journal = {Journal of Biological Chemistry}, number = {2}, pages = {828 -- 830}, publisher = {American Society for Biochemistry and Molecular Biology}, title = {{Brain-derived neurotrophic factor increases neurotrophin-3 expression in cerebellar granule neurons}}, doi = {10.1016/s0021-9258(17)42186-7}, volume = {269}, year = {1994}, }