Misshapen mediates actin-based cell contraction during zebrafish epiboly and Drosophila dorsal closure - Köppen, Mathias; Fernández, Beatriz; Carvalho, Lara; Jacinto, António; Heisenberg, Carl-Philipp J (Mechanisms of Development, 2005)
The spreading of an epithelial cell sheet over a substrate is a common process during embryogenesis. Typical examples include epiboly during zebrafish gastrulation and Drosophila dorsal closure. We provide evidence that in both cases, actin-based contraction of the leading edge of the epithelium is of critical importance.
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