---
_id: '4184'
abstract:
- lang: eng
text: Epithelial morphogenesis depends on coordinated changes in cell shape, a process
that is still poorly understood. During zebrafish epiboly and Drosophila dorsal
closure, cell-shape changes at the epithelial margin are of critical importance.
Here evidence is provided for a conserved mechanism of local actin and myosin
2 recruitment during theses events. It was found that during epiboly of the zebrafish
embryo, the movement of the outer epithelium (enveloping layer) over the yolk
cell surface involves the constriction of marginal cells. This process depends
on the recruitment of actin and myosin 2 within the yolk cytoplasm along the margin
of the enveloping layer. Actin and myosin 2 recruitment within the yolk cytoplasm
requires the Ste20-like kinase Msn1, an orthologue of Drosophila Misshapen. Similarly,
in Drosophila, actin and myosin 2 localization and cell constriction at the margin
of the epidermis mediate dorsal closure and are controlled by Misshapen. Thus,
this study has characterized a conserved mechanism underlying coordinated cell-shape
changes during epithelial morphogenesis.
article_processing_charge: No
author:
- first_name: Mathias
full_name: Köppen, Mathias
last_name: Köppen
- first_name: Beatriz
full_name: Fernández, Beatriz
last_name: Fernández
- first_name: Lara
full_name: Carvalho, Lara
last_name: Carvalho
- first_name: António
full_name: Jacinto, António
last_name: Jacinto
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
citation:
ama: 'Köppen M, Fernández B, Carvalho L, Jacinto A, Heisenberg C-PJ. Coordinated
cell-shape changes control epithelial movement in zebrafish and Drosophila. Development.
2006;133(14):2671-2681. doi:doi:
10.1242/dev.02439'
apa: 'Köppen, M., Fernández, B., Carvalho, L., Jacinto, A., & Heisenberg, C.-P.
J. (2006). Coordinated cell-shape changes control epithelial movement in zebrafish
and Drosophila. Development. Company of Biologists. https://doi.org/doi: 10.1242/dev.02439'
chicago: 'Köppen, Mathias, Beatriz Fernández, Lara Carvalho, António Jacinto, and
Carl-Philipp J Heisenberg. “Coordinated Cell-Shape Changes Control Epithelial
Movement in Zebrafish and Drosophila.” Development. Company of Biologists,
2006. https://doi.org/doi: 10.1242/dev.02439.'
ieee: M. Köppen, B. Fernández, L. Carvalho, A. Jacinto, and C.-P. J. Heisenberg,
“Coordinated cell-shape changes control epithelial movement in zebrafish and Drosophila,”
Development, vol. 133, no. 14. Company of Biologists, pp. 2671–2681, 2006.
ista: Köppen M, Fernández B, Carvalho L, Jacinto A, Heisenberg C-PJ. 2006. Coordinated
cell-shape changes control epithelial movement in zebrafish and Drosophila. Development.
133(14), 2671–2681.
mla: 'Köppen, Mathias, et al. “Coordinated Cell-Shape Changes Control Epithelial
Movement in Zebrafish and Drosophila.” Development, vol. 133, no. 14, Company
of Biologists, 2006, pp. 2671–81, doi:doi:
10.1242/dev.02439.'
short: M. Köppen, B. Fernández, L. Carvalho, A. Jacinto, C.-P.J. Heisenberg, Development
133 (2006) 2671–2681.
date_created: 2018-12-11T12:07:27Z
date_published: 2006-07-15T00:00:00Z
date_updated: 2021-01-12T07:55:08Z
day: '15'
doi: 'doi: 10.1242/dev.02439'
extern: '1'
intvolume: ' 133'
issue: '14'
language:
- iso: eng
month: '07'
oa_version: None
page: 2671 - 2681
publication: Development
publication_status: published
publisher: Company of Biologists
publist_id: '1935'
status: public
title: Coordinated cell-shape changes control epithelial movement in zebrafish and
Drosophila
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 133
year: '2006'
...