---
res:
  bibo_abstract:
  - Cell migration is central to embryonic development, homeostasis and disease(1),
    processes in which cells move as part of a group or individually. Whereas the
    mechanisms controlling single-cell migration in vitro are relatively well understood(2-4),
    less is known about the mechanisms promoting the motility of individual cells
    in vivo. In particular, it is not clear how cells that form blebs in their migration
    use those protrusions to bring about movement in the context of the three-dimensional
    cellular environment(5,6). Here we show that the motility of chemokine-guided
    germ cells within the zebrafish embryo requires the function of the small Rho
    GTPases Rac1 and RhoA, as well as E-cadherin-mediated cell-cell adhesion. Using
    fluorescence resonance energy transfer we demonstrate that Rac1 and RhoA are activated
    in the cell front. At this location, Rac1 is responsible for the formation of
    actin-rich structures, and RhoA promotes retrograde actin flow. We propose that
    these actin-rich structures undergoing retrograde flow are essential for the generation
    of E-cadherin-mediated traction forces between the germ cells and the surrounding
    tissue and are therefore crucial for cell motility in vivo.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Elena
      foaf_name: Kardash, Elena
      foaf_surname: Kardash
  - foaf_Person:
      foaf_givenName: Michal
      foaf_name: Reichman-Fried, Michal
      foaf_surname: Reichman Fried
  - foaf_Person:
      foaf_givenName: Jean
      foaf_name: Maître, Jean-Léon
      foaf_surname: Maître
  - foaf_Person:
      foaf_givenName: Bijan
      foaf_name: Boldajipour, Bijan
      foaf_surname: Boldajipour
  - foaf_Person:
      foaf_givenName: Ekaterina
      foaf_name: Ekaterina Papusheva
      foaf_surname: Papusheva
      foaf_workInfoHomepage: http://www.librecat.org/personId=41DB591E-F248-11E8-B48F-1D18A9856A87
  - foaf_Person:
      foaf_givenName: Esther
      foaf_name: Messerschmidt, Esther-Maria
      foaf_surname: Messerschmidt
  - foaf_Person:
      foaf_givenName: Carl
      foaf_name: Heisenberg, Carl-Philipp
      foaf_surname: Heisenberg
  - foaf_Person:
      foaf_givenName: Erez
      foaf_name: Raz, Erez
      foaf_surname: Raz
  bibo_doi: 10.1038/ncb2003
  bibo_issue: '1'
  bibo_volume: 12
  dct_date: 2010^xs_gYear
  dct_publisher: Nature Publishing Group@
  dct_title: A role for Rho GTPases and cell-cell adhesion in single-cell motility
    in vivo@
...