@article{4194,
  abstract     = {Cells at the anterior boundary of the neural plate (ANB) can induce telencephalic gene expression when transplanted to more posterior regions. Here, we identify a secreted Frizzled-related Wnt antagonist, Tic, that is expressed in ANB cells and can cell nonautonomously promote telencephalic gene expression in a concentration-dependent manner. Moreover, abrogation of Tlc function compromises telencephalic development. We also identify Wnt8b as a locally acting modulator of regional fate in the anterior neural plate and a likely target for antagonism by Tic. Finally, we show that tlc expression is regulated by signals that establish early antero-posterior and dorso-ventral ectodermal pattern. From these studies, we propose that local antagonism of Wnt activity within the anterior ectoderm is required to establish the telencephalon.},
  author       = {Houart, Corinne and Caneparo, Luca and Heisenberg, Carl-Philipp J and Barth, K Anukampa and Take Uchi, Masaya and Wilson, Stephen},
  issn         = {0896-6273},
  journal      = {Neuron},
  number       = {2},
  pages        = {255 -- 265},
  publisher    = {Elsevier},
  title        = {{Establishment of the telencephalon during gastrulation by local antagonism of Wnt signaling}},
  doi          = {10.1016/S0896-6273(02)00751-1},
  volume       = {35},
  year         = {2002},
}