Establishment of the telencephalon during gastrulation by local antagonism of Wnt signaling Houart, Corinne Caneparo, Luca Heisenberg, Carl-Philipp J ; https://orcid.org/0000-0002-0912-4566 Barth, K Anukampa Take Uchi, Masaya Wilson, Stephen Cells at the anterior boundary of the neural plate (ANB) can induce telencephalic gene expression when transplanted to more posterior regions. Here, we identify a secreted Frizzled-related Wnt antagonist, Tic, that is expressed in ANB cells and can cell nonautonomously promote telencephalic gene expression in a concentration-dependent manner. Moreover, abrogation of Tlc function compromises telencephalic development. We also identify Wnt8b as a locally acting modulator of regional fate in the anterior neural plate and a likely target for antagonism by Tic. Finally, we show that tlc expression is regulated by signals that establish early antero-posterior and dorso-ventral ectodermal pattern. From these studies, we propose that local antagonism of Wnt activity within the anterior ectoderm is required to establish the telencephalon. Elsevier 2002 info:eu-repo/semantics/article doc-type:article text http://purl.org/coar/resource_type/c_2df8fbb1 https://research-explorer.ista.ac.at/record/4194 Houart C, Caneparo L, Heisenberg C-PJ, Barth KA, Take Uchi M, Wilson S. Establishment of the telencephalon during gastrulation by local antagonism of Wnt signaling. <i>Neuron</i>. 2002;35(2):255-265. doi:<a href="https://doi.org/10.1016/S0896-6273(02)00751-1">10.1016/S0896-6273(02)00751-1</a> eng info:eu-repo/semantics/altIdentifier/doi/10.1016/S0896-6273(02)00751-1 info:eu-repo/semantics/altIdentifier/issn/0896-6273 info:eu-repo/semantics/altIdentifier/pmid/12160744 info:eu-repo/semantics/closedAccess