article published yes Corinne Houart author Luca Caneparo author Carl-Philipp J Heisenberg author 39427864-F248-11E8-B48F-1D18A9856A870000-0002-0912-4566 K Anukampa Barth author Masaya Take Uchi author Stephen Wilson author Cells at the anterior boundary of the neural plate (ANB) can induce telencephalic gene expression when transplanted to more posterior regions. Here, we identify a secreted Frizzled-related Wnt antagonist, Tic, that is expressed in ANB cells and can cell nonautonomously promote telencephalic gene expression in a concentration-dependent manner. Moreover, abrogation of Tlc function compromises telencephalic development. We also identify Wnt8b as a locally acting modulator of regional fate in the anterior neural plate and a likely target for antagonism by Tic. Finally, we show that tlc expression is regulated by signals that establish early antero-posterior and dorso-ventral ectodermal pattern. From these studies, we propose that local antagonism of Wnt activity within the anterior ectoderm is required to establish the telencephalon. Elsevier2002 eng 0896-6273 1216074410.1016/S0896-6273(02)00751-1 352255 - 265 yes C. Houart, L. Caneparo, C.-P. J. Heisenberg, K. A. Barth, M. Take Uchi, and S. Wilson, “Establishment of the telencephalon during gastrulation by local antagonism of Wnt signaling,” <i>Neuron</i>, vol. 35, no. 2. Elsevier, pp. 255–265, 2002. Houart C, Caneparo L, Heisenberg C-PJ, Barth KA, Take Uchi M, Wilson S. Establishment of the telencephalon during gastrulation by local antagonism of Wnt signaling. <i>Neuron</i>. 2002;35(2):255-265. doi:<a href="https://doi.org/10.1016/S0896-6273(02)00751-1">10.1016/S0896-6273(02)00751-1</a> Houart, Corinne, et al. “Establishment of the Telencephalon during Gastrulation by Local Antagonism of Wnt Signaling.” <i>Neuron</i>, vol. 35, no. 2, Elsevier, 2002, pp. 255–65, doi:<a href="https://doi.org/10.1016/S0896-6273(02)00751-1">10.1016/S0896-6273(02)00751-1</a>. C. Houart, L. Caneparo, C.-P.J. Heisenberg, K.A. Barth, M. Take Uchi, S. Wilson, Neuron 35 (2002) 255–265. Houart, Corinne, Luca Caneparo, Carl-Philipp J Heisenberg, K Anukampa Barth, Masaya Take Uchi, and Stephen Wilson. “Establishment of the Telencephalon during Gastrulation by Local Antagonism of Wnt Signaling.” <i>Neuron</i>. Elsevier, 2002. <a href="https://doi.org/10.1016/S0896-6273(02)00751-1">https://doi.org/10.1016/S0896-6273(02)00751-1</a>. Houart C, Caneparo L, Heisenberg C-PJ, Barth KA, Take Uchi M, Wilson S. 2002. Establishment of the telencephalon during gastrulation by local antagonism of Wnt signaling. Neuron. 35(2), 255–265. Houart, C., Caneparo, L., Heisenberg, C.-P. J., Barth, K. A., Take Uchi, M., &#38; Wilson, S. (2002). Establishment of the telencephalon during gastrulation by local antagonism of Wnt signaling. <i>Neuron</i>. Elsevier. <a href="https://doi.org/10.1016/S0896-6273(02)00751-1">https://doi.org/10.1016/S0896-6273(02)00751-1</a> 41942018-12-11T12:07:30Z2023-06-07T09:43:19Z