---
_id: '4194'
abstract:
- lang: eng
  text: Cells at the anterior boundary of the neural plate (ANB) can induce telencephalic
    gene expression when transplanted to more posterior regions. Here, we identify
    a secreted Frizzled-related Wnt antagonist, Tic, that is expressed in ANB cells
    and can cell nonautonomously promote telencephalic gene expression in a concentration-dependent
    manner. Moreover, abrogation of Tlc function compromises telencephalic development.
    We also identify Wnt8b as a locally acting modulator of regional fate in the anterior
    neural plate and a likely target for antagonism by Tic. Finally, we show that
    tlc expression is regulated by signals that establish early antero-posterior and
    dorso-ventral ectodermal pattern. From these studies, we propose that local antagonism
    of Wnt activity within the anterior ectoderm is required to establish the telencephalon.
acknowledgement: We thank many of our colleagues, especially Randy Moon, for providing  reagents  used
  in this study. This study was  supported by the Wellcome Trust, MRC, and BBSRC to
  S.W.W. and C.H. S.W.W. is a Wellcome Trust Senior Research Fellow.
article_processing_charge: No
article_type: original
author:
- first_name: Corinne
  full_name: Houart, Corinne
  last_name: Houart
- first_name: Luca
  full_name: Caneparo, Luca
  last_name: Caneparo
- first_name: Carl-Philipp J
  full_name: Heisenberg, Carl-Philipp J
  id: 39427864-F248-11E8-B48F-1D18A9856A87
  last_name: Heisenberg
  orcid: 0000-0002-0912-4566
- first_name: K Anukampa
  full_name: Barth, K Anukampa
  last_name: Barth
- first_name: Masaya
  full_name: Take Uchi, Masaya
  last_name: Take Uchi
- first_name: Stephen
  full_name: Wilson, Stephen
  last_name: Wilson
citation:
  ama: Houart C, Caneparo L, Heisenberg C-PJ, Barth KA, Take Uchi M, Wilson S. Establishment
    of the telencephalon during gastrulation by local antagonism of Wnt signaling.
    <i>Neuron</i>. 2002;35(2):255-265. doi:<a href="https://doi.org/10.1016/S0896-6273(02)00751-1">10.1016/S0896-6273(02)00751-1</a>
  apa: Houart, C., Caneparo, L., Heisenberg, C.-P. J., Barth, K. A., Take Uchi, M.,
    &#38; Wilson, S. (2002). Establishment of the telencephalon during gastrulation
    by local antagonism of Wnt signaling. <i>Neuron</i>. Elsevier. <a href="https://doi.org/10.1016/S0896-6273(02)00751-1">https://doi.org/10.1016/S0896-6273(02)00751-1</a>
  chicago: Houart, Corinne, Luca Caneparo, Carl-Philipp J Heisenberg, K Anukampa Barth,
    Masaya Take Uchi, and Stephen Wilson. “Establishment of the Telencephalon during
    Gastrulation by Local Antagonism of Wnt Signaling.” <i>Neuron</i>. Elsevier, 2002.
    <a href="https://doi.org/10.1016/S0896-6273(02)00751-1">https://doi.org/10.1016/S0896-6273(02)00751-1</a>.
  ieee: C. Houart, L. Caneparo, C.-P. J. Heisenberg, K. A. Barth, M. Take Uchi, and
    S. Wilson, “Establishment of the telencephalon during gastrulation by local antagonism
    of Wnt signaling,” <i>Neuron</i>, vol. 35, no. 2. Elsevier, pp. 255–265, 2002.
  ista: Houart C, Caneparo L, Heisenberg C-PJ, Barth KA, Take Uchi M, Wilson S. 2002.
    Establishment of the telencephalon during gastrulation by local antagonism of
    Wnt signaling. Neuron. 35(2), 255–265.
  mla: Houart, Corinne, et al. “Establishment of the Telencephalon during Gastrulation
    by Local Antagonism of Wnt Signaling.” <i>Neuron</i>, vol. 35, no. 2, Elsevier,
    2002, pp. 255–65, doi:<a href="https://doi.org/10.1016/S0896-6273(02)00751-1">10.1016/S0896-6273(02)00751-1</a>.
  short: C. Houart, L. Caneparo, C.-P.J. Heisenberg, K.A. Barth, M. Take Uchi, S.
    Wilson, Neuron 35 (2002) 255–265.
date_created: 2018-12-11T12:07:30Z
date_published: 2002-07-18T00:00:00Z
date_updated: 2023-06-07T09:43:19Z
day: '18'
doi: 10.1016/S0896-6273(02)00751-1
extern: '1'
external_id:
  pmid:
  - '12160744'
intvolume: '        35'
issue: '2'
language:
- iso: eng
month: '07'
oa_version: None
page: 255 - 265
pmid: 1
publication: Neuron
publication_identifier:
  issn:
  - 0896-6273
publication_status: published
publisher: Elsevier
publist_id: '1925'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Establishment of the telencephalon during gastrulation by local antagonism
  of Wnt signaling
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 35
year: '2002'
...