{"page":"85 - 94","oa_version":"Published Version","main_file_link":[{"url":"https://www.sciencedirect.com/science/article/pii/S0012160697985110?via%3Dihub","open_access":"1"}],"date_updated":"2022-08-18T13:54:19Z","volume":184,"external_id":{"pmid":["9142986 "]},"year":"1997","intvolume":"       184","extern":"1","doi":"10.1006/dbio.1997.8511","acknowledgement":"We thank C. Thisse and Q. Xu for the kind gift of hggl and rtk2 cDNA, respectively. We are grateful to S. Wilson and R. Warga for many valuable comments on earlier versions of this manuscript. We also thank R. Geisler, D. Gilmour, M. Granato, I Odenthal, F. Pellegri, S. Schulte-Merker, and F. v. Eeden for critical reading of the manuscript. ","citation":{"short":"C.-P.J. Heisenberg, C. Nüsslein Volhard, Developmental Biology 184 (1997) 85–94.","chicago":"Heisenberg, Carl-Philipp J, and Christiane Nüsslein Volhard. “The Function of Silberblick in the Positioning of the Eye Anlage in the Zebrafish Embryo.” <i>Developmental Biology</i>. Elsevier, 1997. <a href=\"https://doi.org/10.1006/dbio.1997.8511\">https://doi.org/10.1006/dbio.1997.8511</a>.","ama":"Heisenberg C-PJ, Nüsslein Volhard C. The function of silberblick in the positioning of the eye anlage in the zebrafish embryo. <i>Developmental Biology</i>. 1997;184(1):85-94. doi:<a href=\"https://doi.org/10.1006/dbio.1997.8511\">10.1006/dbio.1997.8511</a>","ieee":"C.-P. J. Heisenberg and C. Nüsslein Volhard, “The function of silberblick in the positioning of the eye anlage in the zebrafish embryo,” <i>Developmental Biology</i>, vol. 184, no. 1. Elsevier, pp. 85–94, 1997.","ista":"Heisenberg C-PJ, Nüsslein Volhard C. 1997. The function of silberblick in the positioning of the eye anlage in the zebrafish embryo. Developmental Biology. 184(1), 85–94.","mla":"Heisenberg, Carl-Philipp J., and Christiane Nüsslein Volhard. “The Function of Silberblick in the Positioning of the Eye Anlage in the Zebrafish Embryo.” <i>Developmental Biology</i>, vol. 184, no. 1, Elsevier, 1997, pp. 85–94, doi:<a href=\"https://doi.org/10.1006/dbio.1997.8511\">10.1006/dbio.1997.8511</a>.","apa":"Heisenberg, C.-P. J., &#38; Nüsslein Volhard, C. (1997). The function of silberblick in the positioning of the eye anlage in the zebrafish embryo. <i>Developmental Biology</i>. Elsevier. <a href=\"https://doi.org/10.1006/dbio.1997.8511\">https://doi.org/10.1006/dbio.1997.8511</a>"},"publication_status":"published","type":"journal_article","month":"04","date_created":"2018-12-11T12:07:33Z","pmid":1,"article_type":"original","title":"The function of silberblick in the positioning of the eye anlage in the zebrafish embryo","_id":"4201","oa":1,"day":"01","quality_controlled":"1","publication":"Developmental Biology","abstract":[{"lang":"eng","text":"In zebrafish, as in other vertebrates, an initially singular eye held within the neural plate has to split during morphogenesis to allow the development of two separated eyes. It has been suggested that anterior progression of midline tissue within the neural plate is involved in the bilateralization of the eye held. Mutations in the recently identified silberblick (slb) gene cause an incomplete separation of the eyes. During gastrulation and early somitogenesis, the ventral midline of the central nervous system (CNS) together with the underlying axial mesendoderm is shortened and broadened in slb embryos. While in wild-type embryos the ventral CNS midline extends to the anterior limit of the neural plate at the end of gastrulation, there is a gap between the anterior tip of the ventral CNS midline and the anterior edge of the neural plate in slb. To investigate the cause for the shortening of the ventral CNS midline in slb we determined the fate of labeled ventral CNS midline cells in wild-type and slb embryos at different stages of development. In slb, anterior migration of ventral CNS midline cells is impaired, which indicates that migration of these cells is needed for elongation of the ventral CNS midline. The anterior shortening of the ventral CNS midline in slb leads to medial instead of bilateral induction of optic stalks followed by a partial fusion of the eyes at later developmental stages. The analysis of the sIb phenotype indicates that anterior migration of midline cells within the neural plate is required for proper induction and subsequent bilateralization of an initially singular eye field. These findings may therefore provide a starting point in elucidating the role of neural plate morphogenesis in positioning of the eyes. (C) 1997 Academic Press."}],"scopus_import":"1","publist_id":"1917","status":"public","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publisher":"Elsevier","language":[{"iso":"eng"}],"article_processing_charge":"No","issue":"1","publication_identifier":{"eissn":["0012-1606"]},"author":[{"first_name":"Carl-Philipp J","last_name":"Heisenberg","full_name":"Heisenberg, Carl-Philipp J","id":"39427864-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-0912-4566"},{"full_name":"Nüsslein Volhard, Christiane","last_name":"Nüsslein Volhard","first_name":"Christiane"}],"date_published":"1997-04-01T00:00:00Z"}