---
_id: '4209'
abstract:
- lang: eng
  text: We have identified widerborst (wdb), a B' regulatory subunit of PP2A, as a
    conserved component of planar cell polarization mechanisms in both Drosophila
    and in zebrafish. In Drosophila, wdb acts at two steps during planar polarization
    of wing epithelial cells. It is required to organize tissue polarity proteins
    into proximal and distal cortical domains, thus determining wing hair orientation.
    It is also needed to generate the polarized membrane outgrowth that becomes the
    wing hair. Widerborst activates the catalytic subunit of PP2A and localizes to
    the distal side of a planar microtubule web that lies at the level of apical cell
    junctions. This suggests that polarized PP2A activation along the planar microtubule
    web is important for planar polarization. In zebrafish, two wdb homologs are required
    for convergent extension during gastrulation, supporting the conjecture that Drosophila
    planar cell polarization and vertebrate gastrulation movements are regulated by
    similar mechanisms.
acknowledgement: We gratefully acknowledge Bianca Habermann for assistance with bioinformatics,
  Jens Rietdorf and Arshad Desai for help with deconvolution, and Tadashi Uemura and
  Rick Fehon for providing antibodies. Arshad Desai, Christian Dahmann, Tony Hyman
  and Elly Tanaka provided helpful comments on the manuscript. Part of this work was
  performed at the EMBL in Heidelberg.
article_processing_charge: No
article_type: original
author:
- first_name: Michael
  full_name: Hannus, Michael
  last_name: Hannus
- first_name: Fabian
  full_name: Feiguin, Fabian
  last_name: Feiguin
- first_name: Carl-Philipp J
  full_name: Heisenberg, Carl-Philipp J
  id: 39427864-F248-11E8-B48F-1D18A9856A87
  last_name: Heisenberg
  orcid: 0000-0002-0912-4566
- first_name: Suzanne
  full_name: Eaton, Suzanne
  last_name: Eaton
citation:
  ama: Hannus M, Feiguin F, Heisenberg C-PJ, Eaton S. Planar cell polarization requires
    Widerborst, a B′ regulatory subunit of protein phosphatase 2A. <i>Development</i>.
    2002;129(14):3493-3503. doi:<a href="https://doi.org/10.1242/dev.129.14.3493">10.1242/dev.129.14.3493</a>
  apa: Hannus, M., Feiguin, F., Heisenberg, C.-P. J., &#38; Eaton, S. (2002). Planar
    cell polarization requires Widerborst, a B′ regulatory subunit of protein phosphatase
    2A. <i>Development</i>. Company of Biologists. <a href="https://doi.org/10.1242/dev.129.14.3493">https://doi.org/10.1242/dev.129.14.3493</a>
  chicago: Hannus, Michael, Fabian Feiguin, Carl-Philipp J Heisenberg, and Suzanne
    Eaton. “Planar Cell Polarization Requires Widerborst, a B′ Regulatory Subunit
    of Protein Phosphatase 2A.” <i>Development</i>. Company of Biologists, 2002. <a
    href="https://doi.org/10.1242/dev.129.14.3493">https://doi.org/10.1242/dev.129.14.3493</a>.
  ieee: M. Hannus, F. Feiguin, C.-P. J. Heisenberg, and S. Eaton, “Planar cell polarization
    requires Widerborst, a B′ regulatory subunit of protein phosphatase 2A,” <i>Development</i>,
    vol. 129, no. 14. Company of Biologists, pp. 3493–3503, 2002.
  ista: Hannus M, Feiguin F, Heisenberg C-PJ, Eaton S. 2002. Planar cell polarization
    requires Widerborst, a B′ regulatory subunit of protein phosphatase 2A. Development.
    129(14), 3493–3503.
  mla: Hannus, Michael, et al. “Planar Cell Polarization Requires Widerborst, a B′
    Regulatory Subunit of Protein Phosphatase 2A.” <i>Development</i>, vol. 129, no.
    14, Company of Biologists, 2002, pp. 3493–503, doi:<a href="https://doi.org/10.1242/dev.129.14.3493">10.1242/dev.129.14.3493</a>.
  short: M. Hannus, F. Feiguin, C.-P.J. Heisenberg, S. Eaton, Development 129 (2002)
    3493–3503.
date_created: 2018-12-11T12:07:36Z
date_published: 2002-07-15T00:00:00Z
date_updated: 2023-06-06T14:07:49Z
day: '15'
doi: 10.1242/dev.129.14.3493
extern: '1'
external_id:
  pmid:
  - '12091318'
intvolume: '       129'
issue: '14'
language:
- iso: eng
month: '07'
oa_version: None
page: 3493 - 3503
pmid: 1
publication: Development
publication_identifier:
  issn:
  - 0950-1991
publication_status: published
publisher: Company of Biologists
publist_id: '1909'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Planar cell polarization requires Widerborst, a B′ regulatory subunit of protein
  phosphatase 2A
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 129
year: '2002'
...