[{"abstract":[{"text":"In the developing fly wing, secreted morphogens such as Decapentaplegic (Dpp) and Wingless (Wg) form gradients of concentration providing positional information. Dpp forms a longer-range gradient than Wg. To understand how the range is controlled, we measured the four key kinetic parameters governing morphogen spreading: the production rate, the effective diffusion coefficient, the degradation rate, and the immobile fraction. The four parameters had different values for Dpp versus Wg. In addition, Dynamin-dependent endocytosis was required for spreading of Dpp, but not Wg. Thus, the cellular mechanisms of Dpp and Wingless spreading are different: Dpp spreading requires endocytic, intracellular trafficking.","lang":"eng"}],"date_published":"2007-01-26T00:00:00Z","day":"26","title":"Kinetics of morphogen gradient formation","date_updated":"2021-01-12T07:55:26Z","doi":"10.1126/science.1135774","publisher":"American Association for the Advancement of Science","status":"public","publist_id":"1892","citation":{"apa":"Kicheva, A., Pantazis, P., Bollenbach, T., Kalaidzidis, Y., Bittig, T., Julicher, F., &#38; Gonzalez Gaitan, M. (2007). Kinetics of morphogen gradient formation. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.1135774\">https://doi.org/10.1126/science.1135774</a>","ama":"Kicheva A, Pantazis P, Bollenbach T, et al. Kinetics of morphogen gradient formation. <i>Science</i>. 2007;315(5811):521-525. doi:<a href=\"https://doi.org/10.1126/science.1135774\">10.1126/science.1135774</a>","ieee":"A. Kicheva <i>et al.</i>, “Kinetics of morphogen gradient formation,” <i>Science</i>, vol. 315, no. 5811. American Association for the Advancement of Science, pp. 521–525, 2007.","chicago":"Kicheva, Anna, Periklis Pantazis, Tobias Bollenbach, Yannis Kalaidzidis, Thomas Bittig, Frank Julicher, and Marcos Gonzalez Gaitan. “Kinetics of Morphogen Gradient Formation.” <i>Science</i>. American Association for the Advancement of Science, 2007. <a href=\"https://doi.org/10.1126/science.1135774\">https://doi.org/10.1126/science.1135774</a>.","ista":"Kicheva A, Pantazis P, Bollenbach T, Kalaidzidis Y, Bittig T, Julicher F, Gonzalez Gaitan M. 2007. Kinetics of morphogen gradient formation. Science. 315(5811), 521–525.","mla":"Kicheva, Anna, et al. “Kinetics of Morphogen Gradient Formation.” <i>Science</i>, vol. 315, no. 5811, American Association for the Advancement of Science, 2007, pp. 521–25, doi:<a href=\"https://doi.org/10.1126/science.1135774\">10.1126/science.1135774</a>.","short":"A. Kicheva, P. Pantazis, T. Bollenbach, Y. Kalaidzidis, T. Bittig, F. Julicher, M. Gonzalez Gaitan, Science 315 (2007) 521–525."},"publication":"Science","publication_status":"published","extern":1,"volume":315,"month":"01","_id":"4226","author":[{"full_name":"Anna Kicheva","id":"3959A2A0-F248-11E8-B48F-1D18A9856A87","last_name":"Kicheva","first_name":"Anna","orcid":"0000-0003-4509-4998"},{"full_name":"Pantazis, Periklis","last_name":"Pantazis","first_name":"Periklis"},{"full_name":"Bollenbach, Tobias","last_name":"Bollenbach","first_name":"Tobias"},{"last_name":"Kalaidzidis","first_name":"Yannis","full_name":"Kalaidzidis, Yannis"},{"first_name":"Thomas","last_name":"Bittig","full_name":"Bittig, Thomas"},{"first_name":"Frank","last_name":"Julicher","full_name":"Julicher, Frank"},{"full_name":"Gonzalez-Gaitan, Marcos","first_name":"Marcos","last_name":"Gonzalez Gaitan"}],"type":"journal_article","date_created":"2018-12-11T12:07:42Z","page":"521 - 525","issue":"5811","year":"2007","intvolume":"       315","quality_controlled":0}]