---
_id: '4226'
abstract:
- lang: eng
  text: 'In the developing fly wing, secreted morphogens such as Decapentaplegic (Dpp)
    and Wingless (Wg) form gradients of concentration providing positional information.
    Dpp forms a longer-range gradient than Wg. To understand how the range is controlled,
    we measured the four key kinetic parameters governing morphogen spreading: the
    production rate, the effective diffusion coefficient, the degradation rate, and
    the immobile fraction. The four parameters had different values for Dpp versus
    Wg. In addition, Dynamin-dependent endocytosis was required for spreading of Dpp,
    but not Wg. Thus, the cellular mechanisms of Dpp and Wingless spreading are different:
    Dpp spreading requires endocytic, intracellular trafficking.'
author:
- first_name: Anna
  full_name: Anna Kicheva
  id: 3959A2A0-F248-11E8-B48F-1D18A9856A87
  last_name: Kicheva
  orcid: 0000-0003-4509-4998
- first_name: Periklis
  full_name: Pantazis, Periklis
  last_name: Pantazis
- first_name: Tobias
  full_name: Bollenbach, Tobias
  last_name: Bollenbach
- first_name: Yannis
  full_name: Kalaidzidis, Yannis
  last_name: Kalaidzidis
- first_name: Thomas
  full_name: Bittig, Thomas
  last_name: Bittig
- first_name: Frank
  full_name: Julicher, Frank
  last_name: Julicher
- first_name: Marcos
  full_name: Gonzalez-Gaitan, Marcos
  last_name: Gonzalez Gaitan
citation:
  ama: Kicheva A, Pantazis P, Bollenbach T, et al. Kinetics of morphogen gradient
    formation. <i>Science</i>. 2007;315(5811):521-525. doi:<a href="https://doi.org/10.1126/science.1135774">10.1126/science.1135774</a>
  apa: Kicheva, A., Pantazis, P., Bollenbach, T., Kalaidzidis, Y., Bittig, T., Julicher,
    F., &#38; Gonzalez Gaitan, M. (2007). Kinetics of morphogen gradient formation.
    <i>Science</i>. American Association for the Advancement of Science. <a href="https://doi.org/10.1126/science.1135774">https://doi.org/10.1126/science.1135774</a>
  chicago: Kicheva, Anna, Periklis Pantazis, Tobias Bollenbach, Yannis Kalaidzidis,
    Thomas Bittig, Frank Julicher, and Marcos Gonzalez Gaitan. “Kinetics of Morphogen
    Gradient Formation.” <i>Science</i>. American Association for the Advancement
    of Science, 2007. <a href="https://doi.org/10.1126/science.1135774">https://doi.org/10.1126/science.1135774</a>.
  ieee: A. Kicheva <i>et al.</i>, “Kinetics of morphogen gradient formation,” <i>Science</i>,
    vol. 315, no. 5811. American Association for the Advancement of Science, pp. 521–525,
    2007.
  ista: Kicheva A, Pantazis P, Bollenbach T, Kalaidzidis Y, Bittig T, Julicher F,
    Gonzalez Gaitan M. 2007. Kinetics of morphogen gradient formation. Science. 315(5811),
    521–525.
  mla: Kicheva, Anna, et al. “Kinetics of Morphogen Gradient Formation.” <i>Science</i>,
    vol. 315, no. 5811, American Association for the Advancement of Science, 2007,
    pp. 521–25, doi:<a href="https://doi.org/10.1126/science.1135774">10.1126/science.1135774</a>.
  short: A. Kicheva, P. Pantazis, T. Bollenbach, Y. Kalaidzidis, T. Bittig, F. Julicher,
    M. Gonzalez Gaitan, Science 315 (2007) 521–525.
date_created: 2018-12-11T12:07:42Z
date_published: 2007-01-26T00:00:00Z
date_updated: 2021-01-12T07:55:26Z
day: '26'
doi: 10.1126/science.1135774
extern: 1
intvolume: '       315'
issue: '5811'
month: '01'
page: 521 - 525
publication: Science
publication_status: published
publisher: American Association for the Advancement of Science
publist_id: '1892'
quality_controlled: 0
status: public
title: Kinetics of morphogen gradient formation
type: journal_article
volume: 315
year: '2007'
...