---
res:
  bibo_abstract:
  - Suppressive drug interactions, in which one antibiotic can actually help bacterial
    cells to grow faster in the presence of another, occur between protein and DNA
    synthesis inhibitors. Here, we show that this suppression results from nonoptimal
    regulation of ribosomal genes in the presence of DNA stress. Using GFP-tagged
    transcription reporters in Escherichia coli, we find that ribosomal genes are
    not directly regulated by DNA stress, leading to an imbalance between cellular
    DNA and protein content. To test whether ribosomal gene expression under DNA stress
    is nonoptimal for growth rate, we sequentially deleted up to six of the seven
    ribosomal RNA operons. These synthetic manipulations of ribosomal gene expression
    correct the protein-DNA imbalance, lead to improved survival and growth, and completely
    remove the suppressive drug interaction. A simple mathematical model explains
    the nonoptimal regulation in different nutrient environments. These results reveal
    the genetic mechanism underlying an important class of suppressive drug interactions.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Tobias
      foaf_name: Bollenbach, Tobias
      foaf_surname: Bollenbach
  - foaf_Person:
      foaf_givenName: Selwyn
      foaf_name: Quan, Selwyn
      foaf_surname: Quan
  - foaf_Person:
      foaf_givenName: Remy P
      foaf_name: Remy Chait
      foaf_surname: Chait
      foaf_workInfoHomepage: http://www.librecat.org/personId=3464AE84-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0003-0876-3187
  - foaf_Person:
      foaf_givenName: Roy
      foaf_name: Kishony, Roy
      foaf_surname: Kishony
  bibo_doi: 10.1016/j.cell.2009.10.025
  bibo_issue: '4'
  bibo_volume: 139
  dct_date: 2009^xs_gYear
  dct_publisher: Cell Press@
  dct_title: Nonoptimal Microbial Response to Antibiotics Underlies Suppressive Drug
    Interactions@
...