---
res:
  bibo_abstract:
  - Herd immunity, a process in which resistant individuals limit the spread of a
    pathogen among susceptible hosts has been extensively studied in eukaryotes. Even
    though bacteria have evolved multiple immune systems against their phage pathogens,
    herd immunity in bacteria remains unexplored. Here we experimentally demonstrate
    that herd immunity arises during phage epidemics in structured and unstructured
    Escherichia coli populations consisting of differing frequencies of susceptible
    and resistant cells harboring CRISPR immunity. In addition, we develop a mathematical
    model that quantifies how herd immunity is affected by spatial population structure,
    bacterial growth rate, and phage replication rate. Using our model we infer a
    general epidemiological rule describing the relative speed of an epidemic in partially
    resistant spatially structured populations. Our experimental and theoretical findings
    indicate that herd immunity may be important in bacterial communities, allowing
    for stable coexistence of bacteria and their phages and the maintenance of polymorphism
    in bacterial immunity.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Pavel
      foaf_name: Payne, Pavel
      foaf_surname: Payne
      foaf_workInfoHomepage: http://www.librecat.org/personId=35F78294-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-2711-9453
  - foaf_Person:
      foaf_givenName: Lukas
      foaf_name: Geyrhofer, Lukas
      foaf_surname: Geyrhofer
  - foaf_Person:
      foaf_givenName: Nicholas H
      foaf_name: Barton, Nicholas H
      foaf_surname: Barton
      foaf_workInfoHomepage: http://www.librecat.org/personId=4880FE40-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-8548-5240
  - foaf_Person:
      foaf_givenName: Jonathan P
      foaf_name: Bollback, Jonathan P
      foaf_surname: Bollback
      foaf_workInfoHomepage: http://www.librecat.org/personId=2C6FA9CC-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-4624-4612
  bibo_doi: 10.7554/eLife.32035
  bibo_volume: 7
  dct_date: 2018^xs_gYear
  dct_identifier:
  - UT:000431035800001
  dct_language: eng
  dct_publisher: eLife Sciences Publications@
  dct_title: CRISPR-based herd immunity can limit phage epidemics in bacterial populations@
...