--- res: bibo_abstract: - Empirical studies of quantitative genetic variation have revealed robust patterns that are observed both across traits and across species. However, these patterns have no compelling explanation, and some of the observations even appear to be mutually incompatible. We review and extend a major class of theoretical models, ‘mutation–selection models’, that have been proposed to explain quantitative genetic variation. We also briefly review an alternative class of ‘balancing selection models’. We consider to what extent the models are compatible with the general observations, and argue that a key issue is understanding and modelling pleiotropy. We discuss some@eng bibo_authorlist: - foaf_Person: foaf_givenName: Toby foaf_name: Johnson, Toby foaf_surname: Johnson - foaf_Person: foaf_givenName: Nicholas H foaf_name: Nicholas Barton foaf_surname: Barton foaf_workInfoHomepage: http://www.librecat.org/personId=4880FE40-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0002-8548-5240 bibo_doi: 10.1098/rstb.2005.1667 bibo_issue: '1459' bibo_volume: 360 dct_date: 2005^xs_gYear dct_publisher: Royal Society, The@ dct_title: Theoretical models of selection and mutationon quantitative traits@ ...