--- res: bibo_abstract: - Humans and their closest evolutionary relatives, the chimpanzees, differ in ∼1.24% of their genomic DNA sequences. The fraction of these changes accumulated during the speciation processes that have separated the two lineages may be of special relevance in understanding the basis of their differences. We analyzed human and chimpanzee sequence data to search for the patterns of divergence and polymorphism predicted by a theoretical model of speciation. According to the model, positively selected changes should accumulate in chromosomes that present fixed structural differences, such as inversions, between the two species. Protein evolution was more than 2.2 times faster in chromosomes that had undergone structural rearrangements compared with colinear chromosomes. Also, nucleotide variability is slightly lower in rearranged chromosomes. These patterns of divergence and polymorphism may be, at least in part, the molecular footprint of speciation events in the human and chimpanzee lineages. @eng bibo_authorlist: - foaf_Person: foaf_givenName: Arcadio foaf_name: Navarro, Arcadio foaf_surname: Navarro - foaf_Person: foaf_givenName: Nicholas H foaf_name: Barton, Nicholas H foaf_surname: Barton foaf_workInfoHomepage: http://www.librecat.org/personId=4880FE40-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0002-8548-5240 bibo_doi: '10.1126/science.1080600 ' bibo_issue: '5617' bibo_volume: 300 dct_date: 2003^xs_gYear dct_isPartOf: - http://id.crossref.org/issn/0036-8075 dct_language: eng dct_publisher: American Association for the Advancement of Science@ dct_title: Chromosomal speciation and molecular divergence -- Accelerated evolution in rearranged chromosomes@ fabio_hasPubmedId: ' 12690198' ...