---
res:
  bibo_abstract:
  - Natural populations are structured spatially into local populations and genetically
    into diverse ‘genetic backgrounds’ defined by different combinations of selected
    alleles. If selection maintains genetic backgrounds at constant frequency then
    neutral diversity is enhanced. By contrast, if background frequencies fluctuate
    then diversity is reduced. Provided that the population size of each background
    is large enough, these effects can be described by the structured coalescent process.
    Almost all the extant results based on the coalescent deal with a single selected
    locus. Yet we know that very large numbers of genes are under selection and that
    any substantial effects are likely to be due to the cumulative effects of many
    loci. Here, we set up a general framework for the extension of the coalescent
    to multilocus scenarios and we use it to study the simplest model, where strong
    balancing selection acting on a set of n loci maintains 2n backgrounds at constant
    frequencies and at linkage equilibrium. Analytical results show that the expected
    linked neutral diversity increases exponentially with the number of selected loci
    and can become extremely large. However, simulation results reveal that the structured
    coalescent approach breaks down when the number of backgrounds approaches the
    population size, because of stochastic fluctuations in background frequencies.
    A new method is needed to extend the structured coalescent to cases with large
    numbers of backgrounds.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Nicholas H
      foaf_name: Barton, Nicholas H
      foaf_surname: Barton
      foaf_workInfoHomepage: http://www.librecat.org/personId=4880FE40-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-8548-5240
  - foaf_Person:
      foaf_givenName: Arcadio
      foaf_name: Navarro, Arcadio
      foaf_surname: Navarro
  bibo_doi: 10.1017/S0016672301005493
  bibo_issue: '2'
  bibo_volume: 79
  dct_date: 2002^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/0016-6723
  dct_language: eng
  dct_publisher: Cambridge University Press@
  dct_title: 'Extending the coalescent to multilocus systems: the case of balancing
    selection@'
  fabio_hasPubmedId: '12073551'
...