---
res:
  bibo_abstract:
  - "Within hybrid zones that are maintained by a balance between selection and dispersal,
    linkage disequilibrium is generated by the mixing of divergent populations. This
    linkage disequilibrium causes selection on each locus to act on all other loci,
    thereby steepening dines, and generating a barrier to gene flow. Diffusion models
    predict simple relations between the strength of linkage disequilibrium and the
    dispersal rate, σ, and between the barrier to gene flow, B, and the reduction
    in mean fitness, W̄. The aim of this paper is to test the accuracy of these predictions
    by comparison with an exact deterministic model of unlinked loci (r = 0.5). Disruptive
    selection acts on the proportion of alleles from the parental populations (p,
    q): W = exp[-S(4pq)(β)], such that the least fit genotype has fitness e(-S). Where
    β << 1, fitness is reduced for a wide range of intermediate genotypes; where
    β >> 1, fitness is only reduced for those genotypes close to p = 0.5. Even
    with strong epistasis, linkage disequilibria are close to σ2p'(i)p'(j)/r(ij),
    where p'(i), p'(j) are the gradients in allele frequency at loci i, j. The barrier
    to gene flow, which is reflected in the steepening of neutral dines, is given
    by B = ∫(-∞)(∞) (W̄(1/r̄)-1) dx, where r̄, the harmonic mean recombination rate
    between the neural and selected loci, is here 0.5. This is a close approximation
    for weak selection, but underestimates B for strong selection. The barrier is
    stronger for small β, because hybrid fitness is then reduced over a wider range
    of p. The widths of the selected dines are harder to predict: though simple approximations
    are accurate for β = 1, they become inaccurate for extreme β because, then, fitness
    changes sharply with p. Estimates of gene number, made from neutral dines on the
    assumption that selection acts against heterozygotes, are accurate for weak selection
    when β = 1; however, for strong selection, gene number is overestimated. For β
    > 1, gene number is systematically overestimated and, conversely, when β <
    1, it is underestimated.\r\n@eng"
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Nicholas H
      foaf_name: Barton, Nicholas H
      foaf_surname: Barton
      foaf_workInfoHomepage: http://www.librecat.org/personId=4880FE40-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-8548-5240
  - foaf_Person:
      foaf_givenName: Max
      foaf_name: Shpak, Max
      foaf_surname: Shpak
  bibo_doi: 10.1017/S0016672399004334
  bibo_issue: '2'
  bibo_volume: 75
  dct_date: 2000^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/0016-6723
  dct_language: eng
  dct_publisher: Cambridge University Press@
  dct_title: The effects of epistasis on the structure of hybrid zones@
  fabio_hasPubmedId: '10816975'
...