---
res:
  bibo_abstract:
  - The plant hormone gibberellic acid (GA) is a crucial regulator of growth and development.
    The main paradigm of GA signaling puts forward transcriptional regulation via
    the degradation of DELLA transcriptional repressors. GA has also been shown to
    regulate tropic responses by modulation of the plasma membrane incidence of PIN
    auxin transporters by an unclear mechanism. Here we uncovered the cellular and
    molecular mechanisms by which GA redirects protein trafficking and thus regulates
    cell surface functionality. Photoconvertible reporters revealed that GA balances
    the protein traffic between the vacuole degradation route and recycling back to
    the cell surface. Low GA levels promote vacuolar delivery and degradation of multiple
    cargos, including PIN proteins, whereas high GA levels promote their recycling
    to the plasma membrane. This GA effect requires components of the retromer complex,
    such as Sorting Nexin 1 (SNX1) and its interacting, microtubule (MT)-associated
    protein, the Cytoplasmic Linker-Associated Protein (CLASP1). Accordingly, GA regulates
    the subcellular distribution of SNX1 and CLASP1, and the intact MT cytoskeleton
    is essential for the GA effect on trafficking. This GA cellular action occurs
    through DELLA proteins that regulate the MT and retromer presumably via their
    interaction partners Prefoldins (PFDs). Our study identified a branching of the
    GA signaling pathway at the level of DELLA proteins, which, in parallel to regulating
    transcription, also target by a nontranscriptional mechanism the retromer complex
    acting at the intersection of the degradation and recycling trafficking routes.
    By this mechanism, GA can redirect receptors and transporters to the cell surface,
    thus coregulating multiple processes, including PIN-dependent auxin fluxes during
    tropic responses.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Yuliya
      foaf_name: Salanenka, Yuliya
      foaf_surname: Salanenka
      foaf_workInfoHomepage: http://www.librecat.org/personId=46DAAE7E-F248-11E8-B48F-1D18A9856A87
  - foaf_Person:
      foaf_givenName: Inge
      foaf_name: Verstraeten, Inge
      foaf_surname: Verstraeten
      foaf_workInfoHomepage: http://www.librecat.org/personId=362BF7FE-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-7241-2328
  - foaf_Person:
      foaf_givenName: Christian
      foaf_name: Löfke, Christian
      foaf_surname: Löfke
  - foaf_Person:
      foaf_givenName: Kaori
      foaf_name: Tabata, Kaori
      foaf_surname: Tabata
      foaf_workInfoHomepage: http://www.librecat.org/personId=7DAAEDA4-02D0-11E9-B11A-A5A4D7DFFFD0
  - foaf_Person:
      foaf_givenName: Satoshi
      foaf_name: Naramoto, Satoshi
      foaf_surname: Naramoto
  - foaf_Person:
      foaf_givenName: Matous
      foaf_name: Glanc, Matous
      foaf_surname: Glanc
      foaf_workInfoHomepage: http://www.librecat.org/personId=1AE1EA24-02D0-11E9-9BAA-DAF4881429F2
    orcid: 0000-0003-0619-7783
  - foaf_Person:
      foaf_givenName: Jirí
      foaf_name: Friml, Jirí
      foaf_surname: Friml
      foaf_workInfoHomepage: http://www.librecat.org/personId=4159519E-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-8302-7596
  bibo_doi: 10.1073/pnas.1721760115
  bibo_issue: '14'
  bibo_volume: 115
  dct_date: 2018^xs_gYear
  dct_identifier:
  - UT:000429012500073
  dct_language: eng
  dct_publisher: National Academy of Sciences@
  dct_title: Gibberellin DELLA signaling targets the retromer complex to redirect
    protein trafficking to the plasma membrane@
...