{"date_published":"1993-03-25T00:00:00Z","publication_status":"published","day":"25","article_type":"original","page":"305 - 311","language":[{"iso":"eng"}],"date_created":"2018-12-11T12:08:07Z","doi":"10.1038/362305a0","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","_id":"4300","status":"public","date_updated":"2022-03-24T12:22:38Z","citation":{"ama":"Partridge L, Barton NH. Optimality, mutation and the evolution of ageing. <i>Nature</i>. 1993;362:305-311. doi:<a href=\"https://doi.org/10.1038/362305a0\">10.1038/362305a0</a>","ista":"Partridge L, Barton NH. 1993. Optimality, mutation and the evolution of ageing. Nature. 362, 305–311.","short":"L. Partridge, N.H. Barton, Nature 362 (1993) 305–311.","mla":"Partridge, Linda, and Nicholas H. Barton. “Optimality, Mutation and the Evolution of Ageing.” <i>Nature</i>, vol. 362, Nature Publishing Group, 1993, pp. 305–11, doi:<a href=\"https://doi.org/10.1038/362305a0\">10.1038/362305a0</a>.","ieee":"L. Partridge and N. H. Barton, “Optimality, mutation and the evolution of ageing,” <i>Nature</i>, vol. 362. Nature Publishing Group, pp. 305–311, 1993.","apa":"Partridge, L., &#38; Barton, N. H. (1993). Optimality, mutation and the evolution of ageing. <i>Nature</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/362305a0\">https://doi.org/10.1038/362305a0</a>","chicago":"Partridge, Linda, and Nicholas H Barton. “Optimality, Mutation and the Evolution of Ageing.” <i>Nature</i>. Nature Publishing Group, 1993. <a href=\"https://doi.org/10.1038/362305a0\">https://doi.org/10.1038/362305a0</a>."},"title":"Optimality, mutation and the evolution of ageing","pmid":1,"external_id":{"pmid":["8455716"]},"oa_version":"None","volume":362,"year":"1993","type":"journal_article","abstract":[{"lang":"eng","text":"Evolutionary explanations of ageing fall into two classes. Organisms might have evolved the optimal life history, in which survival and fertility late in life are sacrificed for the sake of early reproduction and survival. Alternatively, the life history might be depressed below this optimal compromise by deleterious mutations: because selection against late-acting mutations is weaker, these will impose a greater load on late life. Evidence for the importance of both is emerging, and unravelling their relative importance presents experimentalists with a major challenge."}],"extern":"1","main_file_link":[{"url":"https://www.nature.com/articles/362305a0"}],"intvolume":"       362","publication":"Nature","quality_controlled":"1","publication_identifier":{"issn":["0028-0836"]},"month":"03","author":[{"last_name":"Partridge","first_name":"Linda","full_name":"Partridge, Linda"},{"id":"4880FE40-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8548-5240","first_name":"Nicholas H","last_name":"Barton","full_name":"Barton, Nicholas H"}],"publist_id":"1766","publisher":"Nature Publishing Group","acknowledgement":"We thank B. Charlesworth, T. Chapman. K. Dawson, K. S. Gale. P. Harvey. A. Kondrashov. J. Maynard Smith, M. J. Morgan, M. Slatkin and M. Turell/ for helpful comments and C. Roper for providing the data for Fig. 1. Our work was supported by grants from the NERC and SERC and by the Darwin Trust of Edinburgh.","article_processing_charge":"No"}