{"acknowledgement":"This work was supported by grants from the SERC (GR/H/09928) and NERC (GR/3/8002), and by the Darwin Trust of Edinburgh. Thanks are due to B. Nürnberger for convincing me that population structure does reduce fixation probability, to M. Whitlock for discussions on calculations of effective population size, and to W. G. Hill, P. Keightley and the anonymous referees for their comments.","article_processing_charge":"No","publication_identifier":{"issn":["0016-6723"]},"month":"10","publisher":"Cambridge University Press","publist_id":"1762","author":[{"full_name":"Barton, Nicholas H","first_name":"Nicholas H","orcid":"0000-0002-8548-5240","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","last_name":"Barton"}],"quality_controlled":"1","scopus_import":"1","publication":"Genetics Research","intvolume":"        62","main_file_link":[{"open_access":"1","url":"https://www.cambridge.org/core/journals/genetics-research/article/probability-of-fixation-of-a-favoured-allele-in-a-subdivided-population/3257B4AEC7044AFE40436C2DC15FBC4C#article"}],"abstract":[{"lang":"eng","text":"In a stably subdivided population with symmetric migration, the chance that a favoured allele will be fixed is independent of population structure. However, random extinction introduces an extra component of sampling drift, and reduces the probability of fixation. In this paper, the fixation probability is calculated using the diffusion approximation; comparison with exact solution of the discrete model shows this to be accurate. The key parameters are the rates of selection, migration and extinction, scaled relative to population size (S = 4Ns, M = 4Nm, Λ = 4Nλ); results apply to a haploid model, or to diploids with additive selection. If new colonies derive from many demes, the fixation probability cannot be reduced by more than half. However, if colonies are initially homogeneous, fixation probability can be much reduced. In the limit of low migration and extinction rates (M, Λ 1), it is 2s/{1 + (Λ/MS)(1 −exp(−S))}, whilst in the opposite limit (S  1), it is 4sM/{Λ(Λ + M)}. In the limit of weak selection (M, Λ  1), it is 4sM/{Λ(Λ + M)}. These factors are not the same as the reduction in effective population size (Ne/N), showing that the effects of population structure on selected alleles cannot be understood from the behaviour of neutral markers."}],"oa":1,"extern":"1","year":"1993","type":"journal_article","oa_version":"None","volume":62,"citation":{"ama":"Barton NH. The probability of fixation of a favoured allele in a subdivided population. <i>Genetics Research</i>. 1993;62(2):149-158. doi:<a href=\"https://doi.org/10.1017/S0016672300031748\">10.1017/S0016672300031748</a>","chicago":"Barton, Nicholas H. “The Probability of Fixation of a Favoured Allele in a Subdivided Population.” <i>Genetics Research</i>. Cambridge University Press, 1993. <a href=\"https://doi.org/10.1017/S0016672300031748\">https://doi.org/10.1017/S0016672300031748</a>.","ieee":"N. H. Barton, “The probability of fixation of a favoured allele in a subdivided population,” <i>Genetics Research</i>, vol. 62, no. 2. Cambridge University Press, pp. 149–158, 1993.","apa":"Barton, N. H. (1993). The probability of fixation of a favoured allele in a subdivided population. <i>Genetics Research</i>. Cambridge University Press. <a href=\"https://doi.org/10.1017/S0016672300031748\">https://doi.org/10.1017/S0016672300031748</a>","mla":"Barton, Nicholas H. “The Probability of Fixation of a Favoured Allele in a Subdivided Population.” <i>Genetics Research</i>, vol. 62, no. 2, Cambridge University Press, 1993, pp. 149–58, doi:<a href=\"https://doi.org/10.1017/S0016672300031748\">10.1017/S0016672300031748</a>.","ista":"Barton NH. 1993. The probability of fixation of a favoured allele in a subdivided population. Genetics Research. 62(2), 149–158.","short":"N.H. Barton, Genetics Research 62 (1993) 149–158."},"title":"The probability of fixation of a favoured allele in a subdivided population","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","_id":"4303","status":"public","date_updated":"2022-03-23T15:41:32Z","date_created":"2018-12-11T12:08:09Z","doi":"10.1017/S0016672300031748","issue":"2","language":[{"iso":"eng"}],"article_type":"original","page":"149 - 158","date_published":"1993-10-01T00:00:00Z","day":"01","publication_status":"published"}